Progress in Organ Bioprinting for Regenerative Medicine

Engineering ›› 2024, Vol. 42 ›› Issue (11) : 129 -152. DOI: 10.1016/j.eng.2024.04.023

Research

Xiang Wang ^a^,^#
, Di Zhang ^a^,^#
, Yogendra Pratap Singh ^b^,^c
, Miji Yeo ^b^,^c
, Guotao Deng ^a
, Jiaqi Lai ^a
, Fei Chen ^a^,^*
, Ibrahim T. Ozbolat ^b^,^c^,^d^,^e^,^f^,^g^,^h^,^*
, Yin Yu ^a^,^*

Author information +

^aCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

^bThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA

^cEngineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA

^dDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA

^eMaterials Research Institute, Pennsylvania State University, University Park, PA 16802, USA

^fDepartment of Neurosurgery, Pennsylvania State College of Medicine, Hershey 17033, PA, USA

^gPennsylvania State Cancer Institute, Pennsylvania State University, University Park, PA 16802, USA

^hBiotechnology Research and Application Center, Cukurova University, Adana 01130, Türkiye

^bThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA

^cEngineering Science and Mechanics Department, Pennsylvania State University, University Park, PA 16802, USA

^dDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA

^eMaterials Research Institute, Pennsylvania State University, University Park, PA 16802, USA

^fDepartment of Neurosurgery, Pennsylvania State College of Medicine, Hershey 17033, PA, USA

^gPennsylvania State Cancer Institute, Pennsylvania State University, University Park, PA 16802, USA

^hBiotechnology Research and Application Center, Cukurova University, Adana 01130, Türkiye

E⁃mail addresses: fei.chen1@siat.ac.cn (F. Chen),

ito1@psu.edu (I.T. Ozbolat),

yin.yu@siat.ac.cn(Y. Yu)

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History +

Received	Accepted	Published
2024-01-15	2024-04-27	2024-11-01
Issue Date
2024-04-27

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Abstract

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body’s limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

Graphical abstract

Keywords

Organ printing / Three-dimensional bioprinting / Regenerative medicine / Tissue engineering

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Xiang Wang, Di Zhang, Yogendra Pratap Singh, Miji Yeo, Guotao Deng, Jiaqi Lai, Fei Chen, Ibrahim T. Ozbolat, Yin Yu. Progress in Organ Bioprinting for Regenerative Medicine. Engineering, 2024, 42(11): 129-152 DOI:10.1016/j.eng.2024.04.023