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Innate and adaptive T cells in influenza disease
null
《医学前沿(英文)》 2018年 第12卷 第1期 页码 34-47 doi: 10.1007/s11684-017-0606-8
Influenza is a major global health problem, causing infections of the respiratory tract, often leading to acute pneumonia, life-threatening complications and even deaths. Over the last seven decades, vaccination strategies have been utilized to protect people from complications of influenza, especially groups at high risk of severe disease. While current vaccination regimens elicit strain-specific antibody responses, they fail to generate cross-protection against seasonal, pandemic and avian viruses. Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized. During natural infection, viral replication is initially controlled by innate immunity before adaptive immune responses (T cells and antibody-producing B cells) achieve viral clearance and host recovery. Adaptive T and B cells maintain immunological memory and provide protection against subsequent infections with related influenza viruses. Recent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells) in controlling influenza and linking innate and adaptive immune mechanisms, thus making them attractive targets for vaccination strategies. We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptive CD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel vaccine strategies to elicit cross-protective immunity against different influenza strains and subtypes.
关键词: influenza innate T cells CD4+ and CD8+ T cells vaccination
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 608-620 doi: 10.1007/s11684-021-0836-7
关键词: t(8 21)(q22 q22) AML CD34+CD117dim/ CD34+CD117bri cell population gene expression prognosis
Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018
Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 116-124 doi: 10.1007/s11684-019-0732-6
关键词: Meigs’ syndrome ovarian thecoma-fibroma NLR (neutrophil to lymphocyte ratio) CD4+ T cells glucose metabolism
Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification
《环境科学与工程前沿(英文)》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1674-4
● Simultaneous NH4+/NO3– removal was achieved in the FeS denitrification system
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
《医学前沿(英文)》 2008年 第2卷 第4期 页码 366-369 doi: 10.1007/s11684-008-0070-6
动态二叉树表示环境的A<sup>*sup>算法及其在足球机器人路径规划中的实现
唐平,杨宜民
《中国工程科学》 2002年 第4卷 第9期 页码 50-53
提出采用二叉树表示二维空间的方法,对全局路径规划和局部路径规划进行综合考虑,设计移动机器人在复杂环境下对动态障碍物进行避障的A<sup>*sup>算法。
关键词: 动态二叉树 A<sup>*sup>算法 路径规划
K<sup>+sup> and Na<sup>+sup> fluxes in roots of two Chinese Iris populations
Pinfang LI,Biao ZHANG
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 144-149 doi: 10.15302/J-FASE-2014016
关键词: Iris lactea Pall. var. chinensis (Fisch.) Koidz population K+ and Na+ ion flux non-invasive micro-test technique
《医学前沿(英文)》 页码 907-923 doi: 10.1007/s11684-023-1009-7
Haiping LUO,Bangyu QIN,Guangli LIU,Renduo ZHANG,Yabo TANG,Yanping HOU
《环境科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 522-527 doi: 10.1007/s11783-014-0633-5
Advances of 12<sup>thsup> CAPS research symposium: young chemists and chemical engineers fronts
Guoping Hu, Baiqian Dai
《化学科学与工程前沿(英文)》 2021年 第15卷 第3期 页码 461-463 doi: 10.1007/s11705-020-2026-6
RNA m<sup>6sup>A modification and its function in diseases
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《医学前沿(英文)》 2018年 第12卷 第4期 页码 481-489 doi: 10.1007/s11684-018-0654-8
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.
Enabling nickel ferrocyanide nanoparticles for high-performance ammonium ion storage
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 226-235 doi: 10.1007/s11705-022-2198-3
关键词: nickel ferrocyanides NH4+ electrochemistry Prussian blue aqueous ammonium ion batteries
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1713-1
● Synergistic removal of carbamazepine (CBZ) was obtained in the FeS-S2O82– process.
关键词: FeS S2O82– Carbamazepine DFT calculations Degradation routes
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1385-z
• UASB reactor can work efficiently with high COD/SO42- ratios when SDBS exists.
关键词: Up-flow anaerobic sludge blanket Organic sulfur Sodium dodecylbenzene sulfonate COD/SO42− ratio Microbial community
标题 作者 时间 类型 操作
Clinical significance of CD34<sup>+sup>CD117<sup>dimsup>/CD34<sup>+sup>CD117<sup>brisup> myeloblast-associatedgene expression in t(8;21) acute myeloid leukemia
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
期刊论文
Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018
Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang
期刊论文
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
期刊论文
K<sup>+sup> and Na<sup>+sup> fluxes in roots of two Chinese Iris populations
Pinfang LI,Biao ZHANG
期刊论文
High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast
期刊论文
Advances of 12<sup>thsup> CAPS research symposium: young chemists and chemical engineers fronts
Guoping Hu, Baiqian Dai
期刊论文
Performance and mechanism of carbamazepine removal by FeS-SO process: experimental investigation and DFT calculations
期刊论文