检索范围:
排序: 展示方式:
RNA m6A modification and its function in diseases
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 481-489 doi: 10.1007/s11684-018-0654-8
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.
700 °C 及以上蒸汽温度下先进USC发电厂用耐热材料的研究和开发 Review
Fujio Abe
《工程(英文)》 2015年 第1卷 第2期 页码 211-224 doi: 10.15302/J-ENG-2015031
欧洲、美国、日本已开展蒸汽温度为700 °C 及以上的先进超超临界(A-USC) 发电厂用材料开发项目,以实现更高能效和低二氧化碳排放量。近年来中国、印度等也开展了上述项目的开发和研究。这些项目涉及采用镍基合金更换马氏体9%~12%Cr 钢以用于最高温度的锅炉和涡轮部件,从而在700 °C 及以上温度下提供充足的蠕变强度。为尽量减少对昂贵的镍基合金的需求,马氏体9%~12%Cr 钢可用于A-USC 电厂中的次高温部件(最高温度不超过650 °C)。本文综述了A-USC 电厂厚型材锅炉和涡轮部件用镍基合金和马氏体9%~12%Cr 钢的研究和开发,主要关注高温下基底金属和焊缝的长期蠕变断裂强度、焊缝强度损失、蠕变疲劳性质和显微结构演化。
关键词: 镍基合金 9 %~12 % Cr 钢 蠕变强度 蠕变疲劳性质 焊缝 晶界 显微结构 &gamma &prime M23C6 碳化物
prediction of chip flow, burr formation, and cutting forces in micro end-milling of aluminum 6061-T6
PARENTI, M. ANNONI
《机械工程前沿(英文)》 2017年 第12卷 第2期 页码 203-214 doi: 10.1007/s11465-017-0421-6
Predictive models for machining operations have been significantly improved through numerous methods in recent decades. This study proposed a 3D finite element modeling (3D FEM) approach for the micro end-milling of Al6061-T6. Finite element (FE) simulations were performed under different cutting conditions to obtain realistic numerical predictions of chip flow, burr formation, and cutting forces. FE modeling displayed notable advantages, such as capability to easily handle any type of tool geometry and any side effect on chip formation, including thermal aspect and material property changes. The proposed 3D FE model considers the effects of mill helix angle and cutting edge radius on the chip. The prediction capability of the FE model was validated by comparing numerical model and experimental test results. Burr dimension trends were correlated with force profile shapes. However, the FE predictions overestimated the real force magnitude. This overestimation indicates that the model requires further development.
关键词: 3D finite element modeling micro end-milling cutting force chip formation burr formation
微波辐射下离子液体[RMIm]PF6(R=P, B, C6)的合成及其电导率研究
何永福
《中国工程科学》 2008年 第10卷 第9期 页码 92-95
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
《医学前沿(英文)》 doi: 10.1007/s11684-023-1044-4
关键词: SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab
《医学前沿(英文)》 2023年 第17卷 第4期 页码 714-728 doi: 10.1007/s11684-022-0959-5
关键词: FRMD6 lung cancer mTOR pathway
一种高效的异构车辆集群协同框架 Research Articles
Iftikhar AHMAD1,2,Rafidah Md NOOR2,Zaheed AHMED3,Umm-e-HABIBA3,Naveed AKRAM4, 5,Fausto Pedro GARCÍA MÁRQUEZ6
《信息与电子工程前沿(英文)》 2021年 第22卷 第9期 页码 1247-1259 doi: 10.1631/FITEE.2000260
Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO
Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 340-350 doi: 10.1007/s11705-020-1942-9
关键词: nano AgCl@BaSO4 co-precipitates antibacterial flame resistance PA6 composite PA6 yarn
《医学前沿(英文)》 2023年 第17卷 第3期 页码 458-475 doi: 10.1007/s11684-022-0968-4
关键词: LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous SNP GPI-anchored protein
A rolling 6U parallel mechanism
Zhihuai MIAO, Yanan YAO
《机械工程前沿(英文)》 2011年 第6卷 第1期 页码 96-98 doi: 10.1007/s11465-011-0214-2
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma
Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang
《医学前沿(英文)》 2019年 第13卷 第4期 页码 482-491 doi: 10.1007/s11684-018-0633-0
关键词: LGR6 colon adenocarcinoma immunohistochemistry prognosis
Single and joint effects of HHCB and cadmium on zebrafish (
Lei ZHANG, Jing AN, Qixing ZHOU
《环境科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 360-372 doi: 10.1007/s11783-011-0353-z
关键词: 1 3 4 6 7 8-hexahydro-4 6 6 7 8 8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB) cadmium (Cd) antioxidant biomarker feculent water containing bedloads
后5G与6G天线系统技术演进与创新 Editorial
Bao-yan DUAN
《信息与电子工程前沿(英文)》 2020年 第21卷 第1期 页码 1-3 doi: 10.1631/FITEE.2010000
关键词: None
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1925-1936 doi: 10.1007/s11705-023-2344-6
关键词: Cs2AgBiBr6 nanocrystals visible-light photocatalyst Cs2AgBiBr6/TiO2 heterojunction
Cu-doped Bi/Bi2WO6 catalysts for efficient N2 fixation by photocatalysis
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1412-1422 doi: 10.1007/s11705-023-2312-1
关键词: Bi2WO6 Cu doping work function photocatalytic N2 fixation charge separation
标题 作者 时间 类型 操作
prediction of chip flow, burr formation, and cutting forces in micro end-milling of aluminum 6061-T6
PARENTI, M. ANNONI
期刊论文
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression
期刊论文
一种高效的异构车辆集群协同框架
Iftikhar AHMAD1,2,Rafidah Md NOOR2,Zaheed AHMED3,Umm-e-HABIBA3,Naveed AKRAM4, 5,Fausto Pedro GARCÍA MÁRQUEZ6
期刊论文
Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO
Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang
期刊论文
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodesthe candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors
期刊论文
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma
Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang
期刊论文
All-inorganic TiO/CsAgBiBr composite as highly efficient photocatalyst under visible light irradiation
期刊论文