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《医学前沿(英文)》 2022年 第16卷 第5期 页码 760-765 doi: 10.1007/s11684-021-0899-5
关键词: lung transplantation donation after brain death waitlist
Cooling strategies and transport theories for brain hypothermia resuscitation
LIU Jing
《能源前沿(英文)》 2007年 第1卷 第1期 页码 32-57 doi: 10.1007/s11708-007-0004-z
关键词: mathematical interruption hypothermia metabolic generation
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 411-415 doi: 10.1007/s11684-012-0226-2
Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patients and tramadol possesses potential antidepressant effects. Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-related kinase B (TrkB) is a high affinity catalytic receptor for BDNF. We hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects with significant changes in hippocampal BDNF and TrkB levels in rats. Immobility time of rats receiving different treatment in the forced swimming test (FST) was observed. Levels of BDNF and TrkB in hippocampus were measured by enzyme linked immunosorbent assay. Results showed that tramadol (5 mg/kg) administrated alone neither elicited antidepressant effects nor altered BDNF or TrkB level. However, pretreatment with tramadol (5 mg/kg) enhanced the ketamine (10 mg/kg) -elicited antidepressant effects and upregulated the BDNF and TrkB levels in hippocampus. In conclusion, tramadol pretreatment reinforces the ketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat hippocampus.
关键词: tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B
The influence of brain death on donor liver and the potential mechanisms of protective intervention
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 8-14 doi: 10.1007/s11684-011-0109-y
Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.
关键词: brain death donor liver
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease
《医学前沿(英文)》 2021年 第15卷 第6期 页码 842-866 doi: 10.1007/s11684-021-0865-2
关键词: free-living amoebae central nervous system infection primary amoebic meningoencephalitis granulomatous amoebic encephalitis
Experimental study on the establishment and maintenance of brain death model with pigs
ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi
《医学前沿(英文)》 2007年 第1卷 第2期 页码 161-166 doi: 10.1007/s11684-007-0030-6
富含sn-2 DHA脂质对大脑的益处及其酶法合成综述 Review
金俊, 金青哲, 王兴国, Casimir C. Akoh
《工程(英文)》 2020年 第6卷 第4期 页码 424-431 doi: 10.1016/j.eng.2020.02.009
大脑中二十二碳六烯酸(DHA, ω-3脂肪酸)的含量与中枢神经系统的正常发育和功能维持高度相关。甘油酯sn-2位上的DHA可以被肠黏膜更好地吸收,从而实现机体对DHA的高效利用。然而,如今人们在饮食中摄入较多的饱和脂肪或富含ω-6脂肪酸的油脂,而摄入较少的DHA,从而导致了部分个体在行为和神经生理学方面的缺陷。为了全面了解DHA对大脑的有益功能,本文系统介绍了天然油脂甘油骨架上DHA的位置分布(sn-2和sn-1,3位)特征,并讨论了DHA补充和通过肠-脑轴传递信息的潜在功能机制。肠-脑轴包含的多条双向信息通道为DHA、肠道菌群和大脑健康的相互作用提供了新的研究思路。为了在日常饮食中摄入更多的sn-2 DHA,我们建议通过更为高效和经济的酯交换制造技术生产富含sn-2 DHA脂质,其中需要解决的关键技术包括强化酶的特异性和优化纯化工艺。这类饮食可满足对sn-2 ω-3脂质有强烈需求的人群,特别是婴儿、儿童、孕妇和哺乳期妇女。
关键词: DHA 和 sn-2 DHA 单甘酯 大脑 肠-脑轴 结构脂质
从脑科学到人工智能 Review
范静涛, 方璐, 吴嘉敏, 郭雨晨, 戴琼海
《工程(英文)》 2020年 第6卷 第3期 页码 248-252 doi: 10.1016/j.eng.2019.11.012
回顾人工智能(artificial intelligence, AI)的发展历史,我们可以清晰地看到脑科学给AI领域带来的巨大突破,如深度学习。目前,尽管AI及其应用的发展趋势已经超越了人类的预期,但AI与人类智能之间仍然存在着难以逾越的鸿沟。从脑科学到AI、从了解大脑到模拟大脑,在脑科学与AI研究之间建立起一座桥梁已经成为一种迫切需求。为此,我们首先需要通过研究新型脑成像技术来探索脑科学的秘密,建立大脑的动态连接图谱以及将神经科学实验与理论、模型和统计学相结合等。在此基础上,我们将进一步研究新一代AI理论和方法,从而建立起从机器感知和机器学习到机器思维和机器决策的颠覆性模型和工作模式。与此同时,本文还将讨论在脑科学启发新一代AI过程中的一些机遇与挑战。
关键词: 人工智能,脑科学
Clean air captures attention whereas pollution distracts: evidence from brain activities
《环境科学与工程前沿(英文)》 2023年 第18卷 第4期 doi: 10.1007/s11783-024-1801-x
● We find air pollution distracts attention and reveal the neurocognitive mechanisms.
关键词: Air pollution Attention Disengagement Performance Event-related potential
Dietary Lipid Intervention in the Prevention of Brain Aging
Wei Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Min Du,Jiazeng Sun,Juan Chen,Yixuan Li,Changhao Sun,Xingen Lei,Xue Zhang,Fazheng Ren,
《工程(英文)》 doi: 10.1016/j.eng.2023.04.012
关键词: Brain aging Nutritional intervention Phospholipids Phosphatidylcholine Phosphatidylserine Plasmalogen
Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov
《医学前沿(英文)》 2019年 第13卷 第4期 页码 420-426 doi: 10.1007/s11684-019-0688-6
关键词: stroke blood–brain barrier autoimmunity innate immunity inflammation cell death
蒋昌俊,王俊丽
《中国工程科学》 2018年 第20卷 第6期 页码 93-100 doi: 10.15302/J-SSCAE-2018.06.015
人工智能(AI)旨在模拟人脑中信息存储和处理机制等智能行为,使机器具有一定程度的智能水平。随着互联网、大数据、云计算和深度学习等新一代信息技术的飞速发展,目前AI领域的研究和应用已经取得重要进展。本文将深入分析与AI密切相关的计算机科学、控制科学、类脑智能、人脑智能等学科或领域之间的交融与历史演进;指出神经科学、脑科学与认知科学中有关脑的结构与功能机制的研究成果,为构建智能计算模型提供了重要的启发,并从逻辑模型及系统、神经元及网络模型、视觉神经分层机制等方面,分别阐述智能的驱动与发展;最后从互联网的计算理论、AI的演算和计算的融合、类脑智能的模型和机理、AI对神经科学的推动作用、反馈计算的算法设计与控制系统的能级五个方面,对AI的发展趋势进行了展望。
Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured
YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming
《医学前沿(英文)》 2008年 第2卷 第3期 页码 239-243 doi: 10.1007/s11684-008-0045-7
关键词: Glyceraldehyde-3-phosphate dehydrogenase comparative constant unfavorable independent
GUO Tiecheng, CAO Xuebing, XIA Limin
《医学前沿(英文)》 2008年 第2卷 第4期 页码 406-409 doi: 10.1007/s11684-008-0078-y
基于驾驶脑的智能驾驶车辆硬件平台架构 Article
李德毅,高洪波
《工程(英文)》 2018年 第4卷 第4期 页码 464-470 doi: 10.1016/j.eng.2018.07.015
不同智能驾驶试验平台的传感器型号、数量、安装位置各不相同,导致传感器信息处理模块也各不相同;不同驾驶地图,其提供信息的粒度也没有固定标准,由此构成的智能驾驶系统软件模块的数量、接口各不相同。基于以驾驶脑为核心的智能驾驶车辆软件与硬件架构,决策模块将不直接与传感器信息处理模块发生关联,通过驾驶认知的形式化语言,将驾驶认知形式化,由驾驶脑认知形成决策。驾驶认知的形式化降低了传感器数量、类型、安装位置的变化对整个软件架构的影响,使得软件架构可以在不同传感器配置车辆平台上方便地移植。
标题 作者 时间 类型 操作
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death
期刊论文
Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic
null
期刊论文
The influence of brain death on donor liver and the potential mechanisms of protective intervention
null
期刊论文
Experimental study on the establishment and maintenance of brain death model with pigs
ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi
期刊论文
Dietary Lipid Intervention in the Prevention of Brain Aging
Wei Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Min Du,Jiazeng Sun,Juan Chen,Yixuan Li,Changhao Sun,Xingen Lei,Xue Zhang,Fazheng Ren,
期刊论文
Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light
Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov
期刊论文
Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured
YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming
期刊论文
Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the brain
GUO Tiecheng, CAO Xuebing, XIA Limin
期刊论文