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《工程管理前沿(英文)》 2023年 第10卷 第2期 页码 285-299 doi: 10.1007/s42524-022-0197-1
关键词: spatiotemporal differentiation industrial agglomeration low-carbon economy construction machinery industry empirical study
Monocyte subsets and their differentiation tendency after burn injury
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 397-400 doi: 10.1007/s11684-013-0298-7
Monocytes are critical effectors and regulators of immune response. Studying the nomenclature of monocyte subsets may be beneficial for understanding the complex function of monocytes in steady and inflammatory states. A monocyte has the potential to differentiate into dendritic cells or macrophages, and this behavior significantly changes in severely burned patients and mice. The findings in the present study may help enhance understanding on the perturbation of the immune system after severe burn injury.
关键词: monocyte differentiation burn
《环境科学与工程前沿(英文)》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1513-4
• Season and landform influenced spatiotemporal patterns of abundant and rare taxa.
关键词: Rare taxa Biogeography Community assembly Bacterioplankton The Yangtze River
GID complex regulates the differentiation of neural stem cells by destabilizing TET2
《医学前沿(英文)》 doi: 10.1007/s11684-023-1007-9
关键词: TET2 GID complex neural stem cells differentiation of neurons
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
《医学前沿(英文)》 2022年 第16卷 第3期 页码 416-428 doi: 10.1007/s11684-021-0838-5
关键词: abivertinib Btk inhibitor platelet megakaryocyte megakaryopoiesis thrombopoiesis
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
Shixin ZHANG,Shaohua WU,Weimin TIAN
《农业科学与工程前沿(英文)》 2016年 第3卷 第4期 页码 357-362 doi: 10.15302/J-FASE-2016125
关键词: Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1636-x
● Environmental parameters affected functional bacteria and network associations.
关键词: Activated sludge Bacterial community Tank-dependence Network association Functional bacteria
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 420-429 doi: 10.1007/s11684-016-0478-3
Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemogenesis of acute promyelocytic leukemia (APL). We found that CDKN2C was markedly downregulated in APL blasts compared with normal promyelocytes. Chromatin immunoprecipitation combined with quantitative polymerase chain reaction demonstrated that PML/RARα directly bound to the CDKN2C promoter in the APL patient-derived cell line NB4. Luciferase assays indicated that PML/RARα inhibited the CDKN2C promoter activity in a dose-dependent manner. Furthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RARα binding on chromatin in NB4 cells. Functional studies showed that ectopic expression of CDKN2C induced a cell cycle arrest at the G0/G1 phase and a partial differentiation in NB4 cells. Finally, the transcriptional regulation of CDKN2C was validated in primary APL patient samples. Collectively, this study highlights the importance of CDKN2C inactivation in the abnormal cell cycle progression and differentiation block of APL cells and may provide new insights into the study of pathogenesis and targeted therapy of APL.
关键词: CDKN2C acute promyelocytic leukemia cell cycle arrest differentiation
孙曦,吕志民
《信息与电子工程前沿(英文)》 2023年 第24卷 第9期 页码 1273-1286 doi: 10.1631/FITEE.2200304
《医学前沿(英文)》 2022年 第16卷 第2期 页码 227-239 doi: 10.1007/s11684-021-0896-8
关键词: cannabidiol depression radial neural stem cells neurogenesis
Industrial eco-efficiency and its spatial-temporal differentiation in China
Wei YANG, Fengjun JIN, Chengjin WANG, Chen LV
《环境科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 559-568 doi: 10.1007/s11783-012-0400-4
关键词: industrial eco-efficiency data envelopment analysis (DEA) model exploratory spatial data analysis (ESDA)
王文奎,王峰,王 岭
《中国工程科学》 2007年 第9卷 第8期 页码 30-34
艾滋病是一种获得性免疫缺陷综合征,中医学的观点则是正气严重不足。正气依靠精神的支撑,而精神来源于饮食气味及其精微物质 ,精微物质的转化主要靠脏腑功能的正常运化。脏腑功能活动是生命运动的根本。五脏各有所主,各司其职,并且相互和合与平衡,只有当五 脏功能旺盛,并且相互和合时,人体的生命力才会强大,机体“正气”充足,才会有免疫力。在五脏之中,肝、脾、肾三脏功能要保持平衡, 其他各脏功能才会自然趋向平衡与协调,人体才会健康长寿,这就是“三维守恒”法则。
采用嵌入时空距离的混合蚁群算法求解一类受限车辆路径问题 Research Article
冯振辉1,2,肖人彬1,3
《信息与电子工程前沿(英文)》 2023年 第24卷 第7期 页码 1062-1079 doi: 10.1631/FITEE.2200585
Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 330-335 doi: 10.1007/s11684-016-0459-6
The enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) is a histone-lysine N-methyltransferase enzyme that participates in DNA methylation. Ezh2 has also been reported to play crucial roles in stem cell proliferation and differentiation. However, the detailed expression profile of Ezh2 during mouse cochlear development has not been investigated. Here, we examined the spatiotemporal expression of Ezh2 in the cochlea during embryonic and postnatal development. Ezh2 expression began to be observed in the whole otocyst nuclei at embryonic day 9.5 (E9.5). At E12.5, Ezh2 was expressed in the nuclei of the cochlear prosensory epithelium. At E13.5 and E15.5, Ezh2 was expressed from the apical to the basal turns in the nuclei of the differentiating cochlear epithelium. At postnatal day (P) 0 and 7, the Ezh2 expression was located in the nuclei of the cochlear epithelium in all three turns and could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice. Our results provide the basic Ezh2 expression pattern and might be useful for further investigating the detailed role of Ezh2 during cochlear development.
关键词: polycomb repressive complex Ezh2 expression inner ear cochlea development
Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 472-485 doi: 10.1007/s11684-021-0832-y
关键词: neuronal progenitor cells resveratrol cerebral ischemia neuronal differentiation mitochondrial metabolism positron emission tomography
标题 作者 时间 类型 操作
Exploring the coupling relationship of industrial agglomeration and low-carbon economy considering spatiotemporaldifferentiation: An empirical study in China’s construction machinery industry
期刊论文
Distinct community assembly processes underlie significant spatiotemporal dynamics of abundant and rare
期刊论文
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
Shixin ZHANG,Shaohua WU,Weimin TIAN
期刊论文
Tank-dependence of the functionality and network differentiation of activated sludge community in a full-scale
期刊论文
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
null
期刊论文
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
期刊论文
Industrial eco-efficiency and its spatial-temporal differentiation in China
Wei YANG, Fengjun JIN, Chengjin WANG, Chen LV
期刊论文