检索范围:
排序: 展示方式:
王建锋
《中国工程科学》 2003年 第5卷 第8期 页码 23-29
表面上突如其来的SARS本质上却有极规律的内在发展演化机制,遵从初始缓慢增长、加速、减速和稳定终止四个阶段总体道路,自然和社会生活领域众多事件演化都符合这一规律,因而可以运用广义的Logistic基于先期流行的广东SARS感染病例数据,以及尚未结束的北京、全国2003年SARS流行统计数据,借助于最优化分析技术,运用广义的Logistic生长模型对该事件演化特征参量进行了辨识;在此基础上,又借助于广义生长模型的特例研究表明,生长模型模拟结果均与实际数据有很好的一致性,可以用来预测事件的发生演化过程,此次SARS事件堪称生长模型的经典实例。
关键词: SARS 广义的Logistic生长模型 Gompertz分布 预测 最优化
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 603-622 doi: 10.15302/J-FASE -2021397
The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.
Tangchun Wu
《医学前沿(英文)》 2020年 第14卷 第6期 页码 816-819 doi: 10.1007/s11684-020-0823-4
《医学前沿(英文)》 2023年 第17卷 第4期 页码 747-757 doi: 10.1007/s11684-022-0954-x
关键词: COVID-19 convalescent SARS-CoV-2 inactivated vaccination neutralizing antibody B cell response
From SARS to MERS: evidence and speculation
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 377-382 doi: 10.1007/s11684-016-0466-7
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths. Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.
关键词: middle east respiratory syndrome animal origin cross-species transmission monoclonal antibody
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
《医学前沿(英文)》 2021年 第15卷 第4期 页码 644-648 doi: 10.1007/s11684-021-0847-4
关键词: neutralizing antibody antibody cocktail SARS-CoV-2 COVID-19 therapeutic strategy
2003年SARS对中国交通客运量影响的后评价研究——基于本底趋势线全国28个省(市)自治区的分析与估算
孙根年,马丽君
《中国工程科学》 2007年 第9卷 第6期 页码 32-37
2003年SARS是中国公众健康的“灾难”,交通旅客运输因此蒙受巨大损失。结果显示:2003年SARS共造成交通旅客损失10.07亿人次,其中,公路损失8.88亿人次,铁路损失1畅05亿人次,航空损失1611.7万人次,水运损失1943万人次;危机的生命周期从2003年4月开始,5~6月全面爆发,7~8月消减衰退,11~12月有一定的补偿;由于交通区位和SARS疫情的差异,全国28个省(市)自治区客运量损失可划分为4个等级,其中,广东、四川 、 河北3 省客运量损 失超过1亿人次 ; 以 28个省(市) 自治区客运量损失与2003 年本底值 、 SARS 确诊人数建立空间预报模型 , 结果显示 ,客运量本底值边际系数为00.788 46 ,SARS 确诊人数边际系数为0.075
《医学前沿(英文)》 2022年 第16卷 第2期 页码 185-195 doi: 10.1007/s11684-021-0913-y
SARS-CoV-2 variants, immune escape, and countermeasures
《医学前沿(英文)》 2022年 第16卷 第2期 页码 196-207 doi: 10.1007/s11684-021-0906-x
关键词: SARS-CoV-2 COVID-19 vaccine immune escape breakthrough prevention
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen
《医学前沿(英文)》 2020年 第14卷 第6期 页码 746-751 doi: 10.1007/s11684-020-0822-5
Less attention paid to waterborne SARS-CoV-2 spreading in Beijing urban communities
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1398-2
• A survey on individual’s perception of SARS-CoV-2 transmission was conducted.
关键词: Environmental dissemination Risk communication Individual perception
城市污水排放系统中SARS-COV-2的出现和消减 Article
Qian Dong, 蔡俊雄, 刘艳臣, 凌海波, Qi Wang, Luo-Jing Xiang, Shao-Lin Yang, Zheng-Sheng Lu, Yi Liu, Xia Huang, 曲久辉
《工程(英文)》 2023年 第26卷 第7期 页码 214-219 doi: 10.1016/j.eng.2022.03.012
The rapid spread of the coronavirus disease (COVID-19) pandemic in over 200 countries poses a substantial threat to human health. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, can be discharged with feces into the drainage system. However, a comprehensive understanding of the occurrence, presence, and potential transmission of SARS-CoV-2 in sewers, especially in community sewers, is still lacking. This study investigated the virus occurrence by viral nucleic acid testing in vent stacks, septic tanks, and the main sewer outlets of community where confirmed patients had lived during the outbreak of the epidemic in Wuhan, China. The results indicated that the risk of long-term emission of SARS-CoV-2 to the environment via vent stacks of buildings was low after confirmed patients were hospitalized. SARS-CoV-2 were mainly detected in the liquid phase, as opposed to being detected in aerosols, and its RNA in the sewage of septic tanks could be detected for only four days after confirmed patients were hospitalized. The surveillance of SARS-CoV-2 in sewage could be a sensitive indicator for the possible presence of asymptomatic patients in the community, though the viral concentration could be diluted more than 10 times, depending on the sampling site, as indicated by the Escherichia coli (E. coli) test. The comprehensive investigation of the community sewage drainage system is helpful to understand the occurrence characteristics of SARS-CoV-2 in sewage after excretion with feces and the feasibility of sewage surveillance for COVID-19 pandemic monitoring.
Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo
《医学前沿(英文)》 2020年 第14卷 第5期 页码 533-541 doi: 10.1007/s11684-020-0786-5
关键词: coronavirus disease 2019 (COVID-19) SARS-CoV-2 neurological manifestations neuroinvasion brain
标题 作者 时间 类型 操作
ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC
期刊论文
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
期刊论文
Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination
期刊论文
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
期刊论文
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic
期刊论文
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen
期刊论文
城市污水排放系统中SARS-COV-2的出现和消减
Qian Dong, 蔡俊雄, 刘艳臣, 凌海波, Qi Wang, Luo-Jing Xiang, Shao-Lin Yang, Zheng-Sheng Lu, Yi Liu, Xia Huang, 曲久辉
期刊论文