2018, Volume 4, Issue 6
Engineering >> 2018, Volume 4, Issue 6 doi: 10.1016/j.eng.2018.09.009
Engineered Functional Surfaces by Laser Microprocessing for Biomedical Applications
a School of Mechanical Engineering and Automation, Beihang University, Beijing 100083, China
b Hefei Innovation Research Institute, Beihang University, Hefei 230013, China
c Department of Oncology, Center of Excellence, BOE Hefei Digital Hospital Co., Ltd., Hefei 230013, China
d Beijing Long March Space Vehicle Research Institute, First Academy of the China Aerospace Corporation, Beijing 100076, China
e National Engineering Laboratory of Additive Manufacturing for Large Metallic Components, Beihang University, Beijing 100083, China
# These authors contributed equally to this work
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Abstract
Metallic biomaterials are increasingly being used in various medical applications due to their high strength, fracture resistance, good electrical conductivity, and biocompatibility. However, their practical applications have been largely limited due to poor surface performance. Laser microprocessing is an advanced method of enhancing the surface-related properties of biomaterials. This work demonstrates the capability of laser microprocessing for biomedical metallic materials including magnesium and titanium alloys, with potential applications in cell adhesion and liquid biopsy. We investigate laser-material interaction, microstructural evolution, and surface performance, and analyze cell behavior and the surface-enhanced Raman scattering (SERS) effect. Furthermore, we explore a theoretical study on the laser microprocessing of metallic alloys that shows interesting results with potential applications. The results show that cells exhibit good adhesion behavior at the surface of the laser-treated surface, with a preferential direction based on the textured structure. A significant SERS enhancement of 6×103 can be obtained at the laser-textured surface during Raman measurement.
Keywords
Laser microprocessing ; Functional surface ; Metallic alloy ; Niocompatibility ; SERS
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