2023, Volume 29, Issue 10
Engineering >> 2023, Volume 29, Issue 10 doi: 10.1016/j.eng.2023.05.006
Oxygen Penetration Through Full-Thickness Skin by Oxygen-Releasing Sutures for Skin Graft Transplantation
a State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China
b School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia
c School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
d Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China
e Jiangsu Provincial Key Laboratory for Nano Technology, Nanjing University, Nanjing 210093, China
f Jiangsu Food & Pharmaceutical Science College, Huai'an 223003, China
# These authors contributed equally to this work.
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Abstract
The transplantation of full-thickness skin grafts (FTSGs) is important for reconstructing skin barrier and promoting wound healing. Sufficient oxygen supply is closely related to the success of skin grafting. However, full-thickness oxygen delivery is limited by the poor oxygen permeability of skin. Oxygenreleasing sutures (O2 sutures) were developed to facilitate oxygen penetration through full-thickness skin. The O2 sutures delivered 100 times more oxygen than topical gaseous oxygen therapy at a 15 mm depth in the skin model. Under extreme hypoxia (< 0.5% O2, v/v), O2 sutures could also promote endothelial cell proliferation. After the transplantation of FTSGs in mice, O2 sutures accelerated blood re-perfusion and increased the survival area of the skin graft. It is expected that O2 sutures will be adopted in clinical applications to increase the success rate of full-thickness skin transplantation.
Keywords
Wound ; Skin graft transplantation ; Oxygen-releasing sutures ; Full-thickness oxygen delivery
SupplementaryMaterials
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