Due to continuous process scaling, process, voltage, and temperature (PVT) parameter variations have become one of the most problematic issues in circuit design. The resulting correlations among performance metrics lead to a significant para-metric yield loss. Previous algorithms on parametric yield prediction are limited to predicting a single-parametric yield or per-forming balanced optimization for several single-parametric yields. Consequently, these methods fail to predict the multi- parametric yield that optimizes multiple performance metrics simultaneously, which may result in significant accuracy loss. In this paper we suggest an efficient multi-parametric yield prediction framework, in which multiple performance metrics are considered as simultaneous constraint conditions for parametric yield prediction, to maintain the correlations among metrics. First, the framework models the performance metrics in terms of PVT parameter variations by using the adaptive elastic net (AEN) method. Then the parametric yield for a single performance metric can be predicted through the computation of the cumulative distribution function (CDF) based on the multiplication theorem and the Markov chain Monte Carlo (MCMC) method. Finally, a copula-based parametric yield prediction procedure has been developed to solve the multi-parametric yield prediction problem, and to generate an accurate yield estimate. Experimental results demonstrate that the proposed multi-parametric yield prediction framework is able to provide the designer with either an accurate value for parametric yield under specific performance limits, or a multi-parametric yield surface under all ranges of performance limits.