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The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia
Jessica Fredericks, Ruibao Ren
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 452-461 doi: 10.1007/s11684-013-0304-0
BCR/ABL is the causative agent of chronic myelogenous leukemia (CML).Tyrosine177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in mice.transplantation system to demonstrate that addition of oncogenic NRAS (NRASG12D) to a vector containing a BCR/ABLY177F mutant “rescues” the CML phenotype rapidly and efficiently.Results from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced
Keywords: BCR/ABL chronic myelogenous leukemia (CML) RAS RAL
Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals
Weiqi Luo, Yanping Ji, Lu Qu, Zhi Dang, Yingying Xie, Chengfang Yang, Xueqin Tao, Jianmin Zhou, Guining Lu
Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1026-y
Keywords: Heavy metals Eggshell Acid soil remediation BCR sequential extraction
Title Author Date Type Operation
The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia
Jessica Fredericks, Ruibao Ren
Journal Article