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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: regenerative capacity because of the active participation of various signaling pathways, including WntThe Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract:

Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation. The TAC-operated mice were treated with the human equivalent of low-dose aspirin (10 mg·kg−1·d−1); the remaining mice received an equal amount of phosphate buffered saline with 0.65% ethanol, which was used as a vehicle. A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) was treated with the human equivalent of low (10 or 100 µmol·L−1) and high (1000 µmol·L−1) aspirin concentrations in plasma. Changes in the cardiac structure and function were assessed through echocardiography and transmission electron microscopy. Gene expression was determined through RT-PCR and western blot analysis. Results indicated that aspirin treatment abrogated the increased thickness of the left ventricular anterior and posterior walls, the swelling of mitochondria, and the increased surface area in in vivo and in vitro hypertrophy models. Aspirin also normalized the upregulated hypertrophic biomarkers, β-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and b-type natriuretic peptide (BNP). Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β. Therefore, low-dose aspirin possesses significant anti-hypertrophic properties at clinically relevant concentrations for anti-thrombotic therapy. The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects of aspirin.

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: Mechanistically, the knockdown of ACSL5 suppressed the activation of the Wnt/β-cateninpathway by suppressing the palmitoylation modification of Wnt3a.

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiationHere, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectionalregulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear developmentWe concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependentOur findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: Wnt/?deeply understanding of this pathway, more and more genes which contribute to aberrant activation of Wnt

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract: regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway andThese results were considered to indicate that miR-148b could activate the Wnt/β-catenin signal pathway

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulationAxin1 negatively regulates activated Wnt/β-catenin signaling, but little is known regarding its role

Keywords： Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

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Title Author Date Type Operation

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article