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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: Mechanistically, the knockdown of ACSL5 suppressed the activation of the Wnt/β-cateninpathway by suppressing the palmitoylation modification of Wnt3a.

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: Wnt/?-catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and diseasedeeply understanding of this pathway, more and more genes which contribute to aberrant activation of Wnt-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- orThe downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: regenerative capacity because of the active participation of various signaling pathways, including WntThe Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiationHere, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectionalregulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear developmentWe concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependentOur findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: β-catenin is a key molecule involved in both cell-cell adhesion and Wnt signaling pathway.In our study, we found that, in the development of hepatocellular carcinoma (HCC), β-catenin wasThe expression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressingIn addition, immunohistochemical and Western blot analysis of β-catenin revealed that a decreasein the β-catenin protein level was found in 58.3% of HBV-related HCCs 19.2% of non-HBV-related

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract: regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 431-436 doi: 10.1007/s11684-015-0416-9

Abstract: Overexpression of Slit/Robo induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signaling pathways or by altering β-catenin/E-cadherin-mediated cell-cell

Keywords： Slit/Robo     hypermethylation     β-catenin     CXCL12/CXCR4     migration    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway andThese results were considered to indicate that miR-148b could activate the Wnt/β-catenin signal pathway

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulationAxin1 negatively regulates activated Wnt/β-catenin signaling, but little is known regarding its role

Keywords： Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of related proteins

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: The expression of HIF-1α, E-cadherin, β-catenin, and actin was detected using Western blot.The expression of HIF-1α, E-cadherin, and β-catenin in tumor grafts was assayed immunohistochemicallyWestern blot results revealed that the bands of HIF-1α, E-cadherin, β-catenin, and actin proteinsThe expression of E-cadherin, β-catenin, and actin was detected in the H group under hypoxia forfound that there was a significant difference in the expression of HIF-1α, E-cadherin, and β-catenin

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Title Author Date Type Operation

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of related proteins

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article