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ABT-199 1

Akt 1

CXCL12/CXCR4 1

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Slit/Robo 1

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actin 1

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acute myeloid leukemia 1

acyl-CoA synthetase long chain family member 5 1

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: Mechanistically, the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: -catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and disease-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: β-catenin is a key molecule involved in both cell-cell adhesion and Wnt signaling pathway.In our study, we found that, in the development of hepatocellular carcinoma (HCC), β-catenin wasThe expression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressingIn addition, immunohistochemical and Western blot analysis of β-catenin revealed that a decreasein the β-catenin protein level was found in 58.3% of HBV-related HCCs 19.2% of non-HBV-related

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 431-436 doi: 10.1007/s11684-015-0416-9

Abstract: Overexpression of Slit/Robo induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signaling pathways or by altering β-catenin/E-cadherin-mediated cell-cell

Keywords： Slit/Robo     hypermethylation     β-catenin     CXCL12/CXCR4     migration    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- orThe downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of related proteins

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: The expression of HIF-1α, E-cadherin, β-catenin, and actin was detected using Western blot.The expression of HIF-1α, E-cadherin, and β-catenin in tumor grafts was assayed immunohistochemicallyWestern blot results revealed that the bands of HIF-1α, E-cadherin, β-catenin, and actin proteinsThe expression of E-cadherin, β-catenin, and actin was detected in the H group under hypoxia forfound that there was a significant difference in the expression of HIF-1α, E-cadherin, and β-catenin

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Title Author Date Type Operation

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of related proteins

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article