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Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis
Jian Liu, Weiming Wang
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 333-339 doi: 10.1007/s11684-017-0564-1
Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.
Keywords: nephrotic syndrome focal segmental glomerulosclerosis genetic
Developing effective tumor vaccines: basis, challenges and perspectives
XU Qingwen, CHEN Weifeng
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 11-19 doi: 10.1007/s11684-007-0003-9
Keywords: development conventional identification elucidation Successful immunotherapy
Core designing of a new type of TVS-2M FAs: neutronics and thermal-hydraulics design basis limits
Saeed GHAEMI, Farshad FAGHIHI
Frontiers in Energy 2021, Volume 15, Issue 1, Pages 256-278 doi: 10.1007/s11708-018-0583-x
Keywords: TVS-2M FAs core design basis limits VVER-1000 analysis mixture of uranium-gadolinium oxides fuels thermal-hydraulics
Leakage location system for oil pipeline on basis of stress wave detection
WANG Bangfeng, CHEN Renwen
Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3, Pages 307-312 doi: 10.1007/s11465-008-0047-9
Self-organizing method for collaboration in multi-robot system on basis of balance principle
DONG Yangbin, JIANG Jinping, HE Yan
Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3, Pages 283-287 doi: 10.1007/s11465-008-0044-z
Keywords: algorithm self-organizing principle validity Simulation allocation
Clustering economic sectors in China on a life cycle basis to achieve environmental sustainability
Sai LIANG, Tianzhu ZHANG, Xiaoping JIA
Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1, Pages 97-108 doi: 10.1007/s11783-012-0402-2
Keywords: cluster analysis input-output model life cycle material flow analysis sustainable development
Qiaomei RU, Younghee CHO, Qingrong HUANG,
Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4, Pages 399-406 doi: 10.1007/s11705-009-0253-y
Jingqi Zeng, Xiaobin Jia
Engineering 2024, Volume 40, Issue 9, Pages 28-50 doi: 10.1016/j.eng.2024.04.009
Keywords: Artificial intelligence Systems theory Traditional Chinese medicine Material basis Bottom-up
Explicit optimization method for cutting-screw-thread on the basis of dual-RSM
Zhengbao LEI, Shubin WEI, Qingyun DU
Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4, Pages 423-430 doi: 10.1007/s11465-010-0109-7
Keywords: vehicle engineering crash safety explicit method response surface method
Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”
Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg
Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0916-8
Keywords: Metal Mixtures Toxicity Additivity Modeling Interactions
An efficient stochastic dynamic analysis of soil media using radial basis function artificial neural
P. ZAKIAN
Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 4, Pages 470-479 doi: 10.1007/s11709-017-0440-8
Keywords: stochastic analysis random seismic excitation finite element method artificial neural network frequency domain analysis Monte Carlo simulation
Qiang ZHANG, Baoyu LIAO, Shanlin YANG
Frontiers of Engineering Management 2020, Volume 7, Issue 4, Pages 578-591 doi: 10.1007/s42524-020-0137-x
Keywords: blockchain technology intelligent manufacturing networked collaborative manufacturing full life-cycle management manufacturing model innovation
Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 342-352 doi: 10.15302/J-FASE-2017162
Keywords: neutrophil peripheral blood pig poly I:C transcriptome
Xiao-qing ZHANG, Zheng-feng MING
Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 11, Pages 1705-1719 doi: 10.1631/FITEE.1601555
Keywords: Swarm intelligence Grey wolf optimizer Optimization Radial basis function network
The development on seismic design and evaluation of CGNPC after Fukushima accident
Mao Qing,Wu Yingxi,Zhang Jian,Meng Ajun,Zhang Tao,Yang Chunju,Liu Fang
Strategic Study of CAE 2013, Volume 15, Issue 4, Pages 46-51
This paper introduced the seismic design requirements of nuclear power plant, the seismic design situation of the unit in construction or in service, and the serious consequence impacted by earthquake. Then, it described in brief the measures on seismic analysis taken by countries who own nuclear power plants in the world after the Fukushima nuclear accident, and gave a particular introduction about the improvement taken by China Guangdong Nuclear Power Holding Co. Ltd. Finally, this paper presented some steps for the new nuclear power plants at the seismic design and evaluation to enhance the seismic capacity of nuclear power plants through technical means.
Keywords: seismic design basis beyond design basis earthquake seismic margin assessment(SMA) seismic isolation
Title Author Date Type Operation
Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis
Jian Liu, Weiming Wang
Journal Article
Developing effective tumor vaccines: basis, challenges and perspectives
XU Qingwen, CHEN Weifeng
Journal Article
Core designing of a new type of TVS-2M FAs: neutronics and thermal-hydraulics design basis limits
Saeed GHAEMI, Farshad FAGHIHI
Journal Article
Leakage location system for oil pipeline on basis of stress wave detection
WANG Bangfeng, CHEN Renwen
Journal Article
Self-organizing method for collaboration in multi-robot system on basis of balance principle
DONG Yangbin, JIANG Jinping, HE Yan
Journal Article
Clustering economic sectors in China on a life cycle basis to achieve environmental sustainability
Sai LIANG, Tianzhu ZHANG, Xiaoping JIA
Journal Article
Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan
Qiaomei RU, Younghee CHO, Qingrong HUANG,
Journal Article
Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional
Jingqi Zeng, Xiaobin Jia
Journal Article
Explicit optimization method for cutting-screw-thread on the basis of dual-RSM
Zhengbao LEI, Shubin WEI, Qingyun DU
Journal Article
Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”
Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg
Journal Article
An efficient stochastic dynamic analysis of soil media using radial basis function artificial neural
P. ZAKIAN
Journal Article
Application of blockchain in the field of intelligent manufacturing: Theoretical basis, realistic plights
Qiang ZHANG, Baoyu LIAO, Shanlin YANG
Journal Article
Transcriptomic basis of neutrophil ratio variation induced by poly I:C stimulation in porcine peripheral
Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI
Journal Article
An optimized grey wolf optimizer based on a mutation operator and eliminating-reconstructing mechanism and its application
Xiao-qing ZHANG, Zheng-feng MING
Journal Article