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Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 1,   Pages 1-14 doi: 10.1007/s11705-015-1509-3

Abstract: Nanocrystal formulation sheds new light on advanced drug development.

Keywords： drug nanocrystal     nanotechnology     formulation     bioavailability     stabilizers     drug delivery    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Implementation of total Lagrangian formulation for the elasto-plastic analysis of plane steel frames

Bing XIA, Yuching WU, Zhanfei HUANG

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 3,   Pages 257-266 doi: 10.1007/s11709-012-0163-9

Abstract: In this paper, the co-rotational total Lagrangian forms of finite element formulations are derived to perform elasto-plastic analysis for plane steel frames that either experience increasing external loading at ambient temperature or constant external loading at elevated temperatures. Geometric nonlinearities and thermal-expansion effects are considered. A series of programs were developed based on these formulations. To verify the accuracy and efficiency of the nonlinear finite element programs, numerical benchmark tests were performed, and the results from these tests are in a good agreement with the literature. The effects of the nonlinear terms of the stiffness matrices on the computational results were investigated in detail. It was also demonstrated that the influence of geometric nonlinearities on the incremental steps of the finite element analysis for plane steel frames in the presence of fire is limited.

Keywords： co-rotational     total Lagrangian     geometrical nonlinearity     fire     elasto-plastic    

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A novel finite element formulation for static bending analysis of functionally graded porous sandwich

Van Chinh NGUYEN; Trung Thanh TRAN; Trung NGUYEN-THOI; Quoc-Hoa PHAM

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 12,   Pages 1599-1620 doi: 10.1007/s11709-022-0891-4

Abstract: This article aims to propose a finite element formulation based on Quasi-3D theory for the static bendingThe accuracy of the present finite element formulation is verified by comparing the obtained numerical

Keywords： sandwich plates     functionally graded porous     static bending     Quasi-3D theory     Q4 element    

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Robust isogeometric topology optimization for piezoelectric actuators with uniform manufacturability

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 2, doi: 10.1007/s11465-022-0683-5

Abstract: Finally, the RITO formulation for the design of piezoelectric materials is developed, and several numerical

Keywords： piezoelectric actuator     isogeometric topology optimization     uniform manufacturability     robust formulation    

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Controlling interstory drift ratio profiles via topology optimization strategies

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 2,   Pages 165-178 doi: 10.1007/s11709-022-0892-3

Abstract: Two formulations are suggested: one inherits the bound formulation and the other utilizes a p-norm function

Keywords： interstory drift ratio     aggregation function     bound formulation     min–max problem     topology optimization    

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An assessment of surrogate fuel using Bayesian multiple kernel learning model in sight of sooting tendency

Frontiers in Energy 2022, Volume 16, Issue 2,   Pages 277-291 doi: 10.1007/s11708-021-0731-6

Abstract: During surrogate formulation, the BMKL model can be used to shrink the surrogate candidate list in terms

Keywords： sooting tendency     yield sooting index     Bayesian multiple kernel learning     surrogate assessment     surrogate formulation    

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The development formulation and reflection of ISO 18186 and some thinking

Bao Qifan

Strategic Study of CAE 2012, Volume 14, Issue 10,   Pages 23-26

Abstract: internationalized”, firstly formed the national standard GB/T 23678—2009 and proceeded with the formulation

Keywords： international standard development     container RFID（radio frequency identification）    

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 276-279 doi: 10.1007/s11705-014-1426-x

Abstract: Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological

Keywords： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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Non linear modeling of three-dimensional reinforced and fiber concrete structures

Fatiha IGUETOULENE, Youcef BOUAFIA, Mohand Said KACHI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 4,   Pages 439-453 doi: 10.1007/s11709-017-0433-7

Abstract: The formulation of the element has been established for modeling the nonlinear behavior of elastic structuresbehavior of concrete and fiber concrete compressive and tensile strength (stress-strain) the uniaxial formulation

Keywords： numerical modeling     column and beam     nonlinear analysis     fibers     pious     reinforcement     3D formulation     response    

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The application of green surfactants in pesticide formulation

Gao Nan,Zhang Chunhua,Zhang Zongjian

Strategic Study of CAE 2009, Volume 11, Issue 4,   Pages 36-38

Abstract:

The application of green surfactants in pesticide processing was discussed. Formulations, which utilize green surfactants such as AEO, AES, AOS and APG rather than traditional surfactants, were developed in this work. Comparing with traditional surfactants, the application of green surfactants in pesticide processing is of great interest in environmental protection.

Keywords： green surfactant     pesticide processing     environment protection    

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PVC Formulation of Anastrepha suspensa Pheromones Suitable for Field Studies Article

Daniel Kuzmich, Zachary A. Kawagoe, Spencer S. Walse

Engineering 2021, Volume 7, Issue 11,   Pages 1646-1650 doi: 10.1016/j.eng.2020.09.011

Abstract: Here, we report the formulation of male Anastrepha suspensa (Loew) pheromones, (±)-anastrephin

Keywords： Anastrepha     Anastrephin     Epianastrephin     PVC lure     Controlled release    

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Title Author Date Type Operation

Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

Journal Article

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article

Implementation of total Lagrangian formulation for the elasto-plastic analysis of plane steel frames

Bing XIA, Yuching WU, Zhanfei HUANG

Journal Article

A novel finite element formulation for static bending analysis of functionally graded porous sandwich

Van Chinh NGUYEN; Trung Thanh TRAN; Trung NGUYEN-THOI; Quoc-Hoa PHAM

Journal Article

Robust isogeometric topology optimization for piezoelectric actuators with uniform manufacturability

Journal Article

Controlling interstory drift ratio profiles via topology optimization strategies

Journal Article

An assessment of surrogate fuel using Bayesian multiple kernel learning model in sight of sooting tendency

Journal Article

The development formulation and reflection of ISO 18186 and some thinking

Bao Qifan

Journal Article

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Journal Article

Non linear modeling of three-dimensional reinforced and fiber concrete structures

Fatiha IGUETOULENE, Youcef BOUAFIA, Mohand Said KACHI

Journal Article

The application of green surfactants in pesticide formulation

Gao Nan,Zhang Chunhua,Zhang Zongjian

Journal Article

PVC Formulation of Anastrepha suspensa Pheromones Suitable for Field Studies

Daniel Kuzmich, Zachary A. Kawagoe, Spencer S. Walse

Journal Article

Wu Fengchang: Study on the Formulation and Revision of Environmental Quality Standards for Surface Water

吴丰昌(院士)

20 Jan 2021

Conference Videos