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axial piston pump 1

cancer 1

cavitation 1

economical construction 1

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genome-wide association studies (GWAS) 1

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Fast scaling approach based on cavitation conditions to estimate the speed limitation for axial piston

Qun CHAO, Jianfeng TAO, Junbo LEI, Xiaoliang WEI, Chengliang LIU, Yuanhang WANG, Linghui MENG

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 1, Pages 176-185 doi: 10.1007/s11465-020-0616-0

Abstract: Results show that the speed limitation is approximately proportional to the square root of the inlet

Keywords： axial piston pump cavitation speed limitation scaling law

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Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Frontiers in Energy 2012, Volume 6, Issue 2, Pages 148-154 doi: 10.1007/s11708-012-0174-1

Abstract: This research can help to estimate the capacity limitation of nuclear units in the grid.

Keywords： nuclear units capacity overspeed primary frequency control (PFC) second frequency control (SFC)

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Aerodynamic challenges in span length of suspension bridges

XIANG Haifan, GE Yaojun

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2, Pages 153-162 doi: 10.1007/s11709-007-0016-0

Abstract: stability are reviewed, a trial design of a 5 000 m suspension bridge, which is estimated as a reasonable limitation

Keywords： requirement reasonable limitation challenge particular economical construction

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Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 444-450 doi: 10.1007/s11684-012-0225-3

Abstract:

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.

Keywords： genome-wide association studies (GWAS) genetic variant cancer limitation challenge