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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associatedgenes were used for drug resistance surveillance.This study indicated that the antifolate resistance levels of P. vivax parasites were differentacross China and molecular markers could be used to rapidly monitor drug resistance.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1,   Pages 4-4 doi: 10.1007/s11783-021-1438-y

Abstract: Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs).However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system

Keywords： Antibiotic resistance genes     Metal resistance genes     Metagenomic analysis     Microplastics     Mariculture    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: While most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistanceThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistanceEvasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance isaccordingly a key mechanism of drug acquired resistance in cancer therapy.to apoptosis is tightly associated with the emergence of acquired resistance.undergo apoptosis using various means promises an effective strategy for the management of acquired resistance

Keywords： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Transmission of antibiotic resistance genes in agroecosystems: an overview

Jizheng HE, Zhenzhen YAN, Qinglin CHEN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3,   Pages 329-332 doi: 10.15302/J-FASE-2020333

Abstract: antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistanceThe spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens isThe future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems

Keywords： agroecosystem     antibiotic resistance     public health     soil-plant system    

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swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1342-x

Abstract:

• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.

Keywords： Pig manure     Antibiotics     Anaerobic digestion     Resistance genes     Microbial community    

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Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1124-5

Abstract:

Extracellular DNA structure damaged by chlorination was characterized.

Integrity of extracellular ARG genetic information after chlorination was determined.

Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs.

Plasmid DNA/ARGs were less readily broken down than genomic DNA.

The Bioanalyzer methodology effectively documented damage incurred to DNA.

Keywords： Antibiotic resistance     Antibiotic resistance genes (ARGs)     Extracellular DNA/ARGs     Chlorination    

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract:

Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes

Keywords： branched-chain amino acids     leucine     isoleucine     valine     insulin resistance    

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Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistancemetabolic intervention for tumor-infiltrating immunocytes could offer fresh opportunities to break the resistanceHerein, we elaborate potential mechanisms underlying immunotherapy resistance from a novel dimensionhope of offering a reference for targeting metabolic vulnerabilities to circumvent immunotherapeutic resistance

Keywords： immune cell     immunometabolism     metabolic reprogramming     immunotherapy     resistance     tumor microenvironment    

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Characteristics of two transferable aminoglycoside resistance plasmids in

Chengjun Pu, Xiaoyan Gong, Ying Sun

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1119-2

Abstract:

pRKZ3 is a non-conjugative IncQ plasmid, while pKANJ7 is a conjugative IncX plasmid.

The optimal mating time of pKANJ7 varied under different conditions.

Both of the two transferable ARPs had little impact on the growth of their hosts.

A relatively high level of fitness cost was observed for pKANJ7.

The fitness cost of ARPs depended on their hosts.

Keywords： Escherichia coli     Characteristics     Aminoglycoside resistance plasmids     Transfer     Persistence    

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Correlation between tension softening relation and crack extension resistance in concrete

Xiufang ZHANG , Shilang XU ,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 3,   Pages 323-329 doi: 10.1007/s11709-009-0041-2

Abstract: the material fracture energy consumption with crack propagation can be described by a crack extension resistanceThe variation of the crack extension resistance is mainly associated with the energy consumption in theThe crack extension resistance is then a function of the softening curve, which is a basic mechanicalThe relationship between the softening curve and the crack extension resistance curve is then analyzedThe results indicate that the characteristic points of the crack extension resistance curve is closely

Keywords： concrete     fracture process zone     crack extension GR resistance     tension softening curve    

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Environmental effects and risk control of antibiotic resistance genes in the organic solid waste aerobic

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1415-5

Abstract:

• ARGs were detected in livestock manure, sludge, food waste and fermentation dregs.

Keywords： Antibiotic resistance genes     Organic solid waste     Aerobic composting     Livestock manure     Sludge    

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Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline

Mengli Wang, Ruying Li, Qing Zhao

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1127-2

Abstract:

Sludge digestion is critical to control the spread of ARGs from wastewater to soil.

Fate of ARGs in three pretreatment-AD processes was investigated.

UP was more efficient for ARGs removal than AP and THP in pretreatment-AD process.

The total ARGs concentration showed significant correlation with 16S rRNA gene.

The bacteria carrying ARGs could be mainly affiliated with Proteobacteria.

Keywords： Tetracycline resistance genes     Sulfonamide resistance genes     16S rRNA gene     Sludge pretreatment     Anaerobic    

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Analysis of antibiotic resistance of

Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1123-6

Abstract: p>

There was a seasonal difference in antibiotic resistancelistitem>

The E. coli in the Yitong River was found to have multiple antibiotic resistance

Keywords： Yitong River     Coliform bacteria     Antibiotic resistance     Escherichia coli    

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the ultraviolet/chlorine process on microbial community structure, typical pathogens, and antibiotic resistance

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1521-z

Abstract:

• UV/chlorine can effectively remove VBNC pathogens, ARGs and MGEs in reclaimed water.

Keywords： UV/chlorine process     Pathogen     Antibiotic resistance genes     High-throughput qPCR     Reclaimed water    

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Title Author Date Type Operation

Prevalence of antifolate drug resistance markers in in China

Journal Article

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

Transmission of antibiotic resistance genes in agroecosystems: an overview

Jizheng HE, Zhenzhen YAN, Qinglin CHEN

Journal Article

swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance

Journal Article

Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Immunometabolism: a new dimension in immunotherapy resistance

Journal Article

Characteristics of two transferable aminoglycoside resistance plasmids in

Chengjun Pu, Xiaoyan Gong, Ying Sun

Journal Article

Correlation between tension softening relation and crack extension resistance in concrete

Xiufang ZHANG , Shilang XU ,

Journal Article

Environmental effects and risk control of antibiotic resistance genes in the organic solid waste aerobic

Journal Article

Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline

Mengli Wang, Ruying Li, Qing Zhao

Journal Article

Analysis of antibiotic resistance of

Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan

Journal Article

the ultraviolet/chlorine process on microbial community structure, typical pathogens, and antibiotic resistance

Journal Article