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2000 1

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dimer 1

molecular design 1

molecular docking 1

site-directed mutagenesis 1

staphylokinase 1

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Rational Design, Over-expression and Characterization of a Novel Staphylokinase with Lower Tendency of

Song Gang,Yu Min,Mo Wei,Song Houyan

Strategic Study of CAE 2000, Volume 2, Issue 11, Pages 68-72

Abstract:

Staphylokinase has strong tendency to polymerize, which may hamper its clinical use.On the basis of crystal structure of staphylokinase, the dimer structure was modeled by software GRAMMThe computer model of staphylokinase dimer provides a template for the design of improved staphylokinaseA novel variant of staphylokinase (RGD-Sak) was designed based on the model.

Keywords： staphylokinase dimer molecular docking molecular design site-directed mutagenesis