Resource Type

Journal Article 5

Year

2023 2

2021 1

2019 2

Keywords

BCP-ALL 1

Correlation networks 1

Disease subtypes 1

EM/PM subtyping 1

Plasma metabolites 1

Type 2 diabetes mellitus 1

Ultra-weak photon emission 1

aneuploidy 1

diagnosis 1

genetic risk 1

glioma progression 1

hypertrophic cardiomyopathy 1

intratumor heterogeneity 1

machine learning methods 1

membranous nephropathy 1

model 1

molecular classification 1

multiparameter analysis 1

sequence mutations 1

subtypes 1

open ︾

Search scope:

排序： Display mode:

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypesThe EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in pairedtumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypesThe dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

HTML PDF Collect

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 768-780 doi: 10.1007/s11684-023-0982-1

Abstract: cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating potential HCM subtypespatients with HCM were recruited at an average follow-up of 32.78 ± 27.58 months to identify potential HCM subtypesConsequently, two subtypes characterized by different clinical outcomes were identified in HCM.By employing echocardiography and genetic screening for the 46 genes, HCM can be classified into two subtypes

Keywords： machine learning methods     hypertrophic cardiomyopathy     genetic risk    

HTML PDF Collect

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 347-371 doi: 10.1007/s11684-020-0821-6

Abstract: Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed usingrecurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypesThese molecular subtypes could be classified by gene expression patterns with RNA-seq technology.We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL

Keywords： BCP-ALL     subtypes     translocation     aneuploidy     sequence mutations    

HTML PDF Collect

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 618-625 doi: 10.1007/s11684-018-0620-5

Abstract: This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group ( = 248) and non-MN group ( = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.

Keywords： multiparameter analysis     diagnosis     model     membranous nephropathy    

HTML PDF Collect

Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics Combined with Ultra-Weak Photon Emission Article

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Engineering 2019, Volume 5, Issue 5,   Pages 916-923 doi: 10.1016/j.eng.2019.03.011

Abstract: using plasma metabolomics obtained from 44 pre-diabetic subjects to stratify the following TCM-based subtypesto TCM-based subtyping in order to obtain biochemical information for further interpreting disease subtypesPrincipal component analysis of plasma metabolites revealed differences among the TCM-based pre-T2DM subtypesThe results suggest that metabolic differences exist among different TCM-based subtypes of pre-T2DM,and profiling plasma metabolites can be used to discriminate among these subtypes.

Keywords： Type 2 diabetes mellitus     Plasma metabolites     Disease subtypes     Ultra-weak photon emission     Correlation    

HTML PDF Collect

Title Author Date Type Operation

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Journal Article

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Journal Article

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

Journal Article

Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics Combined with Ultra-Weak Photon Emission

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Journal Article