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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory to clinic

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption.

Keywords： target therapy gynecologic malignant tumors clinical trail molecular medicine

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Mathematical and Predictive Models of SARS Epidemic Disease and Mechanism of Prevention and Control

Liu Yunzhong,Xuan Huiyu,Lin Guoxi

Strategic Study of CAE 2004, Volume 6, Issue 9, Pages 60-65

Abstract:

First, based on the law of disease propagation and conservation of population statistics, this paper sets up mathematical models of four kinds of person for SARS, applies mathematical method to analyze the model, and it gets the physiology senses of the mathematical model and mechanism of prevention and control respectively. Second, it sets up predictive models of SARS epidemic disease using BP artificial neural network. According to the data of SARS in Beijing, it predicts and analyzes the model. The experimental results show that the method is simpler, and more effective with high prediction precision。

Keywords： SARS stability trail threshold theory artificial neural network