2013年 第7卷 第4期
《医学前沿（英文）》 >> 2013年 第7卷 第4期 doi: 10.1007/s11684-013-0297-8
Advances in immunopathogenesis of adult immune thrombocytopenia
1. Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China; 2. Shandong University School of Medicine, Jinan, 250012, China
下一篇 上一篇
摘要
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.
京公网安备 11010502051620号
