One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid

2009年第3卷第2期

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《化学科学与工程前沿（英文）》 >> 2009年第3卷第2期 doi: 10.1007/s11705-009-0052-5

One-pot three-component Mannich reaction catalyzed by sucrose char sulfonic acid

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Institute of Fine Catalysis and Synthesis, Hunan Normal University, Changsha 410081, China

发布日期： 2009-06-05

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摘要

Sucrose char sulfonic acid efficiently catalyzed the one-pot three-component Mannich reaction of ketones, aromatic aldehydes and amines in ethanol to afford the corresponding -amino carbonyl compounds in good to excellent yields. A series of heteroaromatic -amino carbonyl compounds can be obtained when using 2-acetylpyrazine as substrate. This reaction can be performed under mild reaction conditions with clean reaction profiles and a simple workup procedure.

关键词

One–pot synthesis ; b-amino ketone ; char sulfonic acid ; 2-acetylpyrazine ; catalysis