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2019年 第13卷 第2期

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《化学科学与工程前沿（英文）》 >> 2019年 第13卷 第2期 doi: 10.1007/s11705-018-1734-7

The synthesis of 6-(tert-butyl)-8-fluoro-2,3-dimethylquinoline carbonate derivatives and their antifungal activity against Pyricularia oryzae

. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.. Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China

录用日期： 2018-07-17 发布日期： 2018-07-17
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A series of novel 6-( -butyl)-8-fluoro-2,3-dimethylquinoline carbonate derivatives were designed and synthesized. Bioassay results showed that some of them exhibited good activity against ( ). It was found that the compound (benzyl (6-( -butyl)-8-fluoro-2,3- dimethylquinolin-4-yl) carbonate) possessed good activity against whatever protective activity (10 mg·L ) or curative activity (25 mg·L ), which was better than that of control tebufloquin. In addition, the frontier molecular orbit results revealed that the compound held higher activity against when the total energy was low and the ClogP was high, which may provide useful information for further design novel fungicides.

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