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Clinical acupuncture research in the West

Xianze Meng, Shifen Xu, Lixing Lao

《医学前沿（英文）》 2011年第5卷第2期页码 134-140 doi: 10.1007/s11684-011-0135-9

摘要： In recent years, acupuncture has rapidly become part of mainstream medicine in the West, where new developments in acupuncture clinical research show extensive progress in evaluating the efficacy and safety of the modality in many categories of disease, especially in pain conditions. Although challenges and difficulties remain, the acupuncture research community has matured and its past experience may lead to even better methods and more innovative research.

关键词： acupuncture clinical research research methodology the West

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Do civil engineering fronts emerge from interdisciplinary research?

《结构与土木工程前沿（英文）》 2023年第17卷第1期页码 1-9 doi: 10.1007/s11709-022-0929-7

摘要： Interdisciplinary research is considered a source of innovativeness and creativity, serving as a key mechanism for creating recombination necessary for the evolution of science systems. The aim of this study is to quantitatively establish the connection between interdisciplinary research and the research fronts that have recently emerged in civil engineering. The degree of interdisciplinarity of the research fronts was measured by developing metrics from bibliographic analyses. As indicated by the consistent increase in the metrics of interdisciplinarity over time, research fronts tend to emerge in studies with increasing diversity in the disciplines involved. The active disciplines involved in the fronts vary over time. The most active disciplines are no longer fundamental but those associated with energy, environment, and sustainable development, focusing on solutions to climate change and integrating intelligence technologies.

关键词： interdisciplinary research research front bibliographic analysis

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Integrating operations research into green logistics: A review

《工程管理前沿（英文）》页码 517-533 doi: 10.1007/s42524-023-0265-1

摘要： Logistical activities have a significant global environmental impact, necessitating the adoption of green logistics practices to mitigate environmental effects. The COVID-19 pandemic has further emphasized the urgency to address the environmental crisis. Operations research provides a means to balance environmental concerns and costs, thereby enhancing the management of logistical activities. This paper presents a comprehensive review of studies integrating operations research into green logistics. A systematic search was conducted in the Web of Science Core Collection database, covering papers published until June 3, 2023. Six keywords (green logistics OR sustainable logistics OR cleaner logistics OR green transportation OR sustainable transportation OR cleaner transportation) were used to identify relevant papers. The reviewed studies were categorized into five main research directions: Green waste logistics, the impact of costs on green logistics, the green routing problem, green transport network design, and emerging challenges in green logistics. The review concludes by outlining suggestions for further research that combines green logistics and operations research, with particular emphasis on investigating the long-term effects of the pandemic on this field.

关键词： green logistics operations research environment literature review

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Numerical simulation and experimental research on the wheel brush sampling process of an asteroid sampler

《机械工程前沿（英文）》 2023年第18卷第2期 doi: 10.1007/s11465-022-0732-0

摘要： To examine the environmental characteristics of the microgravity force and the weathered layer on an asteroid surface, a symmetric wheel brush asteroid sampler is proposed for the collection of particles on the asteroid surface. To study the influence of the wheel brush rotation speed on the sampling efficiency and the driving torque required for the wheel brush, the contact dynamics model between particles and sampling wheel brushes is established and a simulation and experimental verification of the sampling process are conducted. The parameter calibration of the sampled particles is studied first, and the calibrated particle parameters are used in the numerical simulation of the sampling process. The sampling results and the particle stream curves are obtained for the working conditions of different rotation speeds, and the effects of different parameter settings on the sampling efficiency are analyzed. In addition, a set of rotating symmetrical sampling wheel brush devices is built for the ground test, and the dynamic torque sensor is used to test the torque change of the wheel brush during the sampling process. The relationship between the speed of the wheel brush and the driving torque of the wheel brush motor is determined by comparing the simulation results with the test results. Results indicate that when the rotating speed of the wheel brush is faster, the sampling efficiency is higher, and the driving torque required for the sampling wheel brush is greater. Moreover, a numerical simulation analysis of the sampling process of the wheel brush sampler in a microgravity environment is conducted to determine the optimal speed condition, and the brushing test of the wheel brush sampler in the microgravity environment is verified with the drop tower method. This research proposes the structural optimization design and motor selection of a wheel brush asteroid sampler, which provides important reference value and engineering significance.

关键词： asteroid sampling wheel brush sampler discrete element method parameter calibration experimental research

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Construction of a shared system-based real-world clinical research system

null

《医学前沿（英文）》 2014年第8卷第3期页码 382-388 doi: 10.1007/s11684-014-0368-5

摘要：

Hubei Provincial Hospital of Traditional Chinese Medicine established research outpatient clinics to contribute to the major disease-entity research conducted by the National Traditional Chinese Medicine Clinical Research Base and to the construction of the National Traditional Chinese Medicine Treatment and Clinical Research Information Sharing System. With a view of developing a “real-world traditional Chinese medicine clinical research paradigm,” these clinics explored the mode of constructing research outpatient clinics from the aspects of clinical research, health management, and characteristics diagnosis and treatment.

关键词： clinical research shared system real world research outpatient clinic research hospital

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The fundamental theory of traditional Chinese medicine and the consideration in its research strategy

Zhenji Li, Chunbo Xu

《医学前沿（英文）》 2011年第5卷第2期页码 208-211 doi: 10.1007/s11684-011-0126-x

摘要： Stressing the uniqueness and complexity of traditional Chinese medicine (TCM) theory system, this paper analyzes the characteristics of TCM as a discipline from four perspectives: scientific nature, fundamental theory, clinical practice, and pharmacological action. It suggests that when the research strategy of TCM theory is designed, the core theory of TCM should be emphasized on the theoretical research on TCM original thinking theory, TCM theory, Chinese materia medica and formulas, acupuncture and moxibustion, meridians and collaterals, and other related fields. Researchers and practitioners should ensure that the basic research on TCM theory is based on clinical practice, research methods (both traditional and contemporary) are exploited, and methodological innovation is underscored. The rule of TCM development should be followed and the characteristics and advantages of TCM carried forward. Meanwhile, the methods and theory of contemporary science and technology should be exploited to fulfill the goal of inheriting, enriching, and developing the fundamental theory of TCM.

关键词： fundamental theory traditional Chinese medicine research strategy

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Recent progress in hydrodynamic characteristics research and application of annular centrifugal extractors

《化学科学与工程前沿（英文）》 2022年第16卷第6期页码 854-873 doi: 10.1007/s11705-022-2156-0

摘要： The annular centrifugal extractor (ACE) integrates mixing and separation. It has been widely used in many industrial fields because of its low residence time, compact structure, and high mass transfer efficiency. Most of the literature has focused on flow instabilities, flow visualization, and computational fluid dynamics simulations. More recently, research on hydrodynamic behavior and structural optimization has received widespread attention. With the development of ACE technology, applications have been broadened into several new areas. Hence, this paper reviews research progress regarding ACE in terms of hydrodynamic characteristics and the structural improvements. The latest applications covering hydrometallurgy, nuclear fuel reprocessing, bio-extraction, catalytic reaction, and wastewater treatment are presented. We also evaluate future work in droplet breakup and coalescence mechanisms, structural improvements specific to different process requirements, scaling-up methods, and stability and reliability after scaling-up.

关键词： annular centrifugal extractor hydrodynamic characteristics structure optimization the latest application

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HIGHLIGHTS OF THE SPECIAL ISSUE ON “HORTICULTURE RESEARCH FOR GREEN AND SUSTAINABLE DEVELOPMENT” EDITORIAL

《农业科学与工程前沿（英文）》 2021年第8卷第2期 doi: 10.15302/J-FASE-2021396

摘要：

Horticulture is the science and technology of intensively cultivating plants for food, comfort and beautification purposes. Horticulture comprises a wide range of plants and crops including fruit and nut trees, vegetables, edible fungi, and ornamental plants, as well as tea plants also categorized as horticultural crops in some countries including China. Horticultural products are of great value and serve as important dietary sources of antioxidants, vitamins and mineral nutrients for human nutrition and health. Development of a green and sustainable horticulture, producing more and safer fruit and vegetables, is a prerequisite for meeting the ever-increasing demand of the growing human population.

In contrast to other field crops or model plants, horticulture comprises a diverse group of plants ranging from annual to perennial crops that are primarily grown for fresh consumption, which means their cultivation and breeding methods are quite different from other plants, in particular, in somatic variation or bud-sport, grafting propagation, flowering regulation, organogenetic development and postharvest storage systems. Horticultural research mainly focuses on breeding, cultivation and postharvest production related biological questions, to generate knowledge beneficial for cultivar improvement for better quality and year-round supply, to understand biological basis and regulation of quality formation and maintenance. However, owing to the long juvenile period, polyembryony (such as in citrus), large canopy of perennial horticultural plants, especially for fruit crops, basic and applied research has progressed slowly over the years.

Recently, with the rapid development of high-throughput sequencing technology, research in horticulture has entered the new ‘omics’ era. A large number of datasets for horticultural plants obtained through multi-omics including genomics, epigenomics, transcriptomics, proteomics and metabolomics, are now available, which provides many clues for understanding the molecular basis of agronomically important traits. To date, high-quality draft genome sequences have been accomplished for more than 30 horticultural plant species. Based on these reference genomes, resequencing data and newly developed molecular markers, numerous key candidate loci/genes controlling major agronomical traits of perennial horticultural plants have been identified through BSA and GWAS analysis of genetic populations, using these strategies that have been successfully and widely applied to field crops and model plants. One prime example is the genetic locus responsible for citrus polyembryony, which was recently narrowed to an 80-kb region containing 11 candidate genes by comparative genomic analysis of natural citrus populations, identifying CitRWPas the key candidate gene controlling polyembryony. This approach was also applied to QTL mapping and candidate gene mining for fruit quality (including sugar, acid, TSS and carotenoid), fruit shape, fruit size, fruit weight traits in perennial horticultural plants, such as apple, citrus, grape, peach and pear. Also, recent research on the exploitation and utilization of short-juvenile germplasm, like mini-citrus as a model plant, has facilitated functional genomics of fruit crops. A number of functional genes and their molecular mechanisms were successively identified, thereby accelerating the breeding and genetic improvement of main cultivars.

Considering the rapid progress of horticulture research and its indispensable contribution to human health, Frontiers of Agricultural Science and Engineering (FASE) is launching a special issue “Horticulture Research for Green and Sustainable Development”. We invited experts with rich experience in studies of fruit crops, vegetables, ornamentals and tea plants to share their new research achievements and perspectives. A total of 11 articles are included in this special issue. Its research findings cover QTL mapping and key gene mining for maesil weeping traits (https://doi.org/10.15302/J-FASE-2020379) and tea flavonoid metabolism (https://doi.org/10.15302/J-FASE-2021382), functional identification of apple anthocyanin biosynthetic regulator MdMYB1 in controlling ascorbic acid accumulation (https://doi.org/10.15302/J-FASE-2020367), trifoliate orange PtLEA7 protein (https://doi.org/10.15302/J-FASE-2020368) and apple SUMO E3 Ligase MdSIZ1 (https://doi.org/10.15302/J-FASE-2021388) in modulating drought tolerance, tomato D1 protein turnover in photoprotection under sub-high temperature and high light conditions (https://doi.org/10.15302/J-FASE-2021383), and tomato FNC gene in determining the fruit netted-cracking phenotype (https://doi.org/10.15302/J-FASE-2020374). Electrical signals have been reported to be widely generated in response to various environmental changes and are recognized as vital for plant defense, Hu et al. investigated the characteristics of herbivory/wound-elicited electrical signal transduction in tomato, found GLR3.3 and GLR3.5 function as key regulators in leaflet-to-leaflet electrical signal transduction and JA accumulation (https://doi.org/10.15302/J-FASE-2021395). Ploidy manipulation via diploid by tetraploid interploidy crosses is widely used for breeding triploid seedless cultivars. Xia et al. (https://doi.org/10.15302/J-FASE-2021385) produced 182 triploid and 36 tetraploid plants between the diploid Orah mandarin and three allotetraploid somatic hybrids, and further revealed the mechanism of tetraploid hybrids formation by the fertilization of 2n megagametophytes via second division restitution. Two reviews are also included in this special issue. Ji et al. reviewed the recent advances in the regulation of climacteric fruit ripening in terms of phytohormones, transcription factors and epigenetic modifications (https://doi.org/10.15302/J-FASE-2021386). Makkumrai et al. compared the planting locations, climates, cultivation systems, orchard managements, fruit characteristics, and main metabolites between Chinese and Thailand pummelos, highlighted the potential resources for pummelo breeding and genetic improvement (https://doi.org/10.15302/J-FASE-2021391).

As the guest editors, we thank all the authors and reviewers for their great contributions to this special issue on “Horticulture Research for Green and Sustainable Development”, and the FASE editorial team for their great support. We hope the research findings in this issue represent the main concerns of horticulture researchers and producers, and will be beneficial to quality promotion and cultivar improvement of horticultural crops and ensure a green and sustainable development of horticultural industry.

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CAPEES and FESE journal: Together to serve the environmental research community

《环境科学与工程前沿（英文）》 2022年第16卷第5期 doi: 10.1007/s11783-022-1546-3

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The Effect of TRIZ on Research Institute Innovation

He Liu,Qing-hai Yang,Xu Jin

《工程管理前沿（英文）》 2014年第1卷第4期页码 385-389 doi: 10.15302/J-FEM-2014059

摘要： With a background in improving independent innovation capabilities and building a world-class petroleum research institute, scientific innovation is the essence and basis of an innovative framework for a research institute, as well as the inexhaustible driving force for sustainable development. By introducing the theory of inventive problem solving (TRIZ) and combining it with CAI (computer aided innovation) technology, the Research Institute of Petroleum Exploration and Development established an adaptive innovative system by making experiments and fanning out from a point to an area gradually. This article takes the example of the innovative practices of the Department of Petroleum Equipment in Research Institute of Petroleum Exploration and Development, and introduces a building method for the innovative system based on technical innovation, enterprise culture, organizational structure, scheme, and people. It also summarizes the experiences and effects of improving innovative system upon scientific practice which can provide important guidance and reference significance for accelerating independent innovative capability.

关键词： innovative capability TRIZ theory petroleum equipment research institute innovative system

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A critical literature review of bioretention research for stormwater management in cold climate and futureresearch recommendations

Hannah Kratky, Zhan Li, Yijun Chen, Chengjin Wang, Xiangfei Li, Tong Yu

《环境科学与工程前沿（英文）》 2017年第11卷第4期 doi: 10.1007/s11783-017-0982-y

摘要： Bioretention is a popular best management practice of low impact development that effectively restores urban hydrologic characteristics to those of predevelopment and improves water quality prior to conveyance to surface waters. This is achieved by utilizing an engineered system containing a surface layer of mulch, a thick soil media often amended with a variety of materials to improve water quality, a variety of vegetation, and underdrains, depending on the surrounding soil characteristics. Bioretention systems have been studied quite extensively for warm climate applications, but data strongly supporting their long-term efficacy and application in cold climates is sparse. Although it is apparent that bioretention is an effective stormwater management system, its design in cold climate needs further research. Existing cold climate research has shown that coarser media is required to prevent concrete frost from forming. For spring, summer and fall seasons, if sufficient permeability exists to drain the system prior to freezing, peak flow and volume reduction can be maintained. Additionally, contaminants that are removed via filtration are also not impacted by cold climates. In contrary, dissolved contaminants, nutrients, and organics are significantly more variable in their ability to be removed or degraded via bioretention in colder temperatures. Winter road maintenance salts have been shown to negatively impact the removal of some contaminants and positively impact others, while their effects on properly selected vegetation or bacteria health are also not very well understood. Research in these water quality aspects has been inconsistent and therefore requires further study.

关键词： Bioretention Cold climate Low impact development Stormwater

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Engineering management: Global engineering research frontiers

Botao ZHONG, Luting QIU

《工程管理前沿（英文）》 2020年第7卷第1期页码 159-162 doi: 10.1007/s42524-020-0094-4

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Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

《医学前沿（英文）》 2011年第5卷第4期页码 333-335 doi: 10.1007/s11684-011-0166-2

摘要： Cell therapy holds promise in addressing a number of unmet medical needs but despite its considerable impetus, faces numerous challenges including support for translational research in this area. Here, we examine the challenges confronting cell therapy research including the limited funding available for translational research partly due to the uncompetitive nature of required validation studies in cell therapy that of necessity are not hypothesis-driven. Other issues include lack of standardization of definitions of cell products, uncertainty regarding optimum preclinical animal models, duplication of efforts to secure regulatory approval and a lack of uniformity of nomenclature for some cell products. Nonetheless, several initiatives to address all of these issues are underway.

关键词： stem cells clinical trials funding animal models standardization common definitions

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Wheat research and breeding in the new era of a high-quality reference genome

Rudi APPELS

《农业科学与工程前沿（英文）》 2019年第6卷第3期页码 225-232 doi: 10.15302/J-FASE-2019265

摘要：

The publications of the International Wheat Genome Sequencing Consortium (IWGSC) released in August 2018 are reviewed and placed into the context of developments arising from the availability of the high-quality wheat genome assembly.

关键词： assembly technology molecular markers polyploidy transcript networks wheat genome

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Basic consideration of research strategies for head and neck cancer

null

《医学前沿（英文）》 2012年第6卷第4期页码 339-353 doi: 10.1007/s11684-012-0213-7

摘要：

Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although the latter is often excluded and considered as part of endocrine neoplasms). Of these, 90% of HNCs are histologically squamous cell carcinomas originating from the mucosal lining. These malignancies are strongly associated with certain environmental and life-style risk factors, principally tobacco in both smoked and smokeless forms, excessive alcohol consumption, diets poor in antioxidants and essential micronutrients, UV light, chemicals used in certain workplaces, and viruses, principally certain strains of human papillomavirus (HPV) and Epstein-Barr virus (EBV). These cancers are frequently aggressive in their biological behaviour with local invasion and metastasis to lymph nodes in the neck. Since most patients are already at late stages of disease at the time of diagnosis, the desirable practice of early diagnosis (first sign of the malignant lesion at an initial stage ) and early treatment, a critical priority to save lives and retain quality of life, is difficult to implement. Thus, primary prevention has been set as a key goal. This article aims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinical appearance of this group of cancers, and strategies for prevention and early detection. We also suggest basic research strategies on the basis of current knowledge, which should ultimately lead to the improvement of clinical management.

关键词： clinical management head and neck cancer prevention and early detection research strategies risk factors