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2014 1

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Inverted duplication including

Ming TIAN,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Rui HAO,Xiaoxiang HU,Ning LI

《农业科学与工程前沿（英文）》 2014年 第1卷 第2期   页码 121-129 doi: 10.15302/J-FASE-2014026

摘要： The dermal hyperpigmentation phenotype in chickens is controlled by the dominant fibromelanosis allele. One of the ten unique characteristics of Silkie chickens is the fibromelanosis phenotype, which is pigmentation in the dermal layer of the skin and connective tissue. In this study, we found a mutation of fibromelanosis, a genomic rearrangement that included an inverted duplication of ( ), is responsible. We show that, as a stimulator of melanoblast proliferation, expression was increased in silkie embryos and in both skin and muscle throughout adulthood. expression led to an increase in expression of the downstream genes and and was closely relate with the hyperpigmentation phenotype. We examined eight different Chinese chicken breeds showing hyperpigmentation and conclude that this structural genetic variant exists in all fibromelanosis chicken breeds.

关键词： dermal hyperpigmentation     duplication     endothelin 3     Silkie chicken    

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Inverted duplication including

Ming TIAN,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Rui HAO,Xiaoxiang HU,Ning LI

期刊论文