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2015 1

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Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines

Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG

《农业科学与工程前沿（英文）》 2015年 第2卷 第4期   页码 335-340 doi: 10.15302/J-FASE-2015079

摘要： Twelve (+)-nopinone-based 2-amino-3-cyanopyridines 4a–l were synthesized from (–)-β-pinene. The structures of these compounds were characterized by FT-IR, H NMR, and ESI-MS. All the compounds were tested for their anticancer activity against lung cancer cell line A549, gastric cancer cell line MKN45 and breast cancer cell line MCF7 by MTT method, respectively. The results showed that compounds 4f, 4j and 4k had promising anticancer activity against these cancer cell lines, in particular, compound 4f exhibited broad-spectrum and highly efficient anticancer activity against cell lines A549, MKN45 and MCF7 with IC of 23.78, 67.61 and 53.87 µmol·L , respectively. The preliminary analysis of the structure activity relationship implied that the Br or Cl substituted group of the benzene ring in these derivatives significantly contributed to the anticancer activity.

关键词： b-pinene     nopinone     synthesis     2-amino-3-cyanopyridine     anticancer    

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Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines

Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG

期刊论文