Frontiers of Medicine
>> 2008,
Volume 2,
Issue 2
doi:
10.1007/s11684-008-0022-1
Development and clinical trial of a novel bioactive
bone cement
1.The Open University of Hong Kong；Department of Orthopaedics and Traumatology, The University of Hong Kong; 2.Department of Orthopaedics and Traumatology, The University of Hong Kong
Available online: 2008-06-05
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Abstract
Strontium (Sr) and related compounds have become more attractive in the prevention and treatment of osteoporosis. Previously, we developed a novel bioactive bone cement which is mainly composed of strontium-containing hydroxyapatite (Sr-HA) filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) resin. This bone cement is superior to conventional polymethylmethacrylate (PMMA) bone cement in bioactivity, biocompatibility, and osseointegration. It also has shown sufficient mechanical strength properties for its use in percutaneous vertebroplasty (PVP) and total hip replacement (THR). In this paper, we review the and clinical evidence for the effectiveness of this bioactive bone cement.
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