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Frontiers of Medicine >> 2011, Volume 5, Issue 4 doi: 10.1007/s11684-011-0161-7

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

1. Department of Oral and Maxillofacial Surgery; 2. Oral Bioengineering/Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, the Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Available online: 2011-12-05

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Clinical imperatives for the reconstruction of jaw bone defects or resorbed alveolar ridge require new therapies or procedures instead of autologous/allogeneic bone grafts. Regenerative medicine, based on stem cell science and tissue engineering technology, is considered as an ideal alternative strategy for bone regeneration. In this paper, we review the current choices of cell source and strategies on directing the osteogenic differentiation of stem cells. The preclinical animal models for bone regeneration and the key translational points to clinical success in oral and maxillofacial region are also discussed. We propose comprehensive strategies based on stem cell and tissue engineering researches, allowing for clinical application in oral and maxillofacial region.

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