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2019, Volume 13, Issue 5

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Frontiers of Medicine >> 2019, Volume 13, Issue 5 doi: 10.1007/s11684-018-0649-5

Immunoregulatory effects of

. Traditional Chinese Medicine Hospital of Changping District, Beijing 102200, China;.. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China;.. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;.. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100070, China;.. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100070, China

Accepted: 2019-01-02 Available online: 2019-01-02
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Abstract

Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells; ratio of T cell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

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