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Frontiers of Medicine

2020, Volume 14,  Issue 2, Pages 126-135
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    Coronavirus disease 2019 (COVID-19): a clinical update

    . National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.. Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.. Research Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

    Accepted： 2020-04-02 Available online：2020-04-02
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    10.1007/s11684-020-0767-8
    Cite this article
    Min Zhou, Xinxin Zhang, Jieming Qu.Coronavirus disease 2019 (COVID-19): a clinical update[J].Frontiers of Medicine,2020,14(2):126-135.

    Abstract

    Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

    Keywords

    coronavirus disease 2019 ; epidemiology ; pathology ; radiology ; clinical characteristics ; treatment
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