Frontiers of Chemical Science and Engineering
>> 2010,
Volume 4,
Issue 1
doi:
10.1007/s11705-009-0307-1
Research articles
Protein microspheres for pulmonary drug delivery
| Tianjin Crystec Pharmaceutical
Technology Limited, Tianjin 300457, China; |
Available online: 2010-03-05
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Abstract
A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drug delivery (PDD). This technique, based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF process. An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.
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