Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

2014, Volume 8, Issue 3

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Frontiers of Chemical Science and Engineering >> 2014, Volume 8, Issue 3 doi: 10.1007/s11705-014-1425-y

Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.2. School of Pharmacy, Fudan University, Shanghai 200433, China

Available online: 2014-10-11

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Abstract

Theranostic platform, which is equipped with both diagnostic and therapeutic functions, is a promising approach in cancer treatment. From various nanotheranostics studied, iron oxide nanoparticles have advantages since IONPs have good biocompatibility and spatial imaging capability. This review is focused on the IONP-based nanotheranostics for cancer imaging and treatment. The most recent progress for applications of IONP nanotheranostics is summarized, which includes IONP-based diagnosis, magnetic resonance imaging (MRI), multimodal imaging, chemotherapy, hyperthermal therapy, photodynamic therapy, and gene delivery. Future perspectives and challenges are also outlined for the potential development of IONP based theranostics in clinical use.

Keywords

theranostics ; iron oxide nanoparticles ; MRI ; drug delivery ; photothermal therapy ; photodynamic therapy

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