Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

2021, Volume 15, Issue 2

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Frontiers of Chemical Science and Engineering >> 2021, Volume 15, Issue 2 doi: 10.1007/s11705-020-1927-8

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.. Central Lab, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China.. Institute of Hematology, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China

Accepted: 2020-04-09 Available online: 2020-04-09

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Abstract

Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.

Keywords

zeolitic imidazolate framework-8 (ZIF-8) ; synthesis methods ; applications ; drug delivery

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