本文在分析流程工业的特点、运行现状和国际智能制造发展状况的基础上，提出了我国流程工业智能制造的新模式——智能优化制造。在分析流程企业采用的由企业资源计划、制造执行系统、过程控制系统组成的三层架构和控制与管理信息化系统的发展状况基础上，提出了未来流程企业应采用的智能优化制造的架构和系统愿景功能，分析了实现愿景功能所需要攻克的关键共性技术和对自动化、计算机和通信、数据科学挑战的科学问题，提出了突出流程工业战略地位、实施战略规划与顶层设计等发展流程工业智能优化制造的建议。

Based on the in-depth analysis of features of the process industry, the state of art of its operation control, and the global development of intelligent manufacturing, a new mode of intelligent manufacturing for the process industry, i.e., smart and optimal manufacturing, is proposed. After analysis of the development situation of the existing three-tier architecture (consisting of enterprise resource planning, manufacturing execution system, and process control system) and the control and management informatization system adopted by process enterprises, a smart and optimal manufacturing framework and prospects for future process enterprises are presented, followed by the analysis of key generic technologies that are critical for the successful deployment of intelligent manufacturing in the process industry. The fundamental challenges and open scientific problems to be addressed jointly by the communities of automation, computer and communication, and data science are also presented. Moreover, suggestions on the future development and deployment of smart and optimal manufacturing in the process industry are offered, include emphasizing the strategic position of the process industry, actualizing the strategic planning and top-level design.