Promoting technological transformation and intelligence upgrading of the manufacturing industry is an important measure to deepen the supply-side structural reform. However, due to the disproportionation in development of China’s manufacturing industry, how to effectively promote transformation of the industrial base is the major difficulty in China’s industrial policy implementation at the present stage. Since 2013, Zhejiang Province has accumulated rich working experience in terms of advancing technological transformation and intelligence upgrading of the manufacturing industry, and obtained remarkable achievements in the aspects of improving the quality of manufacturing products, easing labor pressure, optimizing the investment structure, and fostering emerging industries. Based on field research of the manufacturing industry in Zhejiang Province, this study summarized the main methods and effects in the aspects of giving play to government guidance, stimulating enterprise initiatives, and optimizing market supply in the process of technological transformation and intelligence upgrading of the manufacturing industry in Zhejiang Province, and proposed policy suggestions for comprehensive promotion of technological transformation and intelligence upgrading of the manufacturing industry in China.