基于现代集成制造的理念、方法、技术、工具，结合实践，提出并研究了一种能改善复杂产品研发时间（T）、质量（Q）、成本（C）、服务（S）的系统工程——称为“复杂系统（产品）集成制造工程”（简称COSIME）。阐述了它的内涵、系统框架和技术体系，并给出了其中具有特点的6类关键技术的阶段研究成果，包括基于人制管理及有关先进制造模式的复杂产品集成制造系统的经营管理模式；基于项目管理理念的异地企业间并行工程方法与技术；复杂产品虚拟样机工程方法与技术；基于分布仿真技术的复杂产品概念设计与性能评估系统；复杂产品质量控制与管理系统；基于PLM及网络技术的两种复杂产品全生命周期活动集成制造支撑平台等。

Based on the theories, methods, technologies and tools of contemporary integrated manufacturing, the Complex System (Product) Integrated Manufacturing Engineering (COSIME) is presented and researched, aiming to improve the T (Time to market), Q (Quality), C (Cost), S (Service) of the complex product development. The connotation, system framework and technology system of COSIME are given. Furthermore, the phased research results of six key technologies are introduced： (1) the management mode of the complex product integrated manufacturing system based on the theory of the ” management of person with ability and institution” and the advanced manufacture patterns; (2) the concurrent engineering methods and techniques for the enterprises dispersed at different sites based on the theory of the project management; (3) the means and technologies of the virtual prototyping engineering for complex product; (4) the concept design and performance evaluation system for complex product based on the advanced distributed interactive simulation technology; (5) the quality control and management system for complex product; (6) the two integrated manufacturing infrastructures for the all lifecycle activities of complex product based on PLM and the grid computing technologies.