
仿生农用杀菌剂银泰的研制与应用
Research on Bionic Fungicide Yintai and Its Application
Meng Zhaoli1、Fang Xiangyang1、Luo Lan1、Shang Jian2
银泰(1-对羟基苯基丁酮)是以银杏外种皮提纯物白果酚为先导化合物仿生合成的一种杀菌剂。其中,银杏果实乙醇粗提物8.3倍和25倍液对苹果腐烂病抑菌率达100%和50%;银杏果实外种皮提纯物白果酚200倍和400倍液对苹果腐烂病病菌抑菌率均为100%。20%银泰微乳剂对苹果腐烂病、番茄灰霉病等4种病菌 EC50 为17.26~48.43mg/L,分别优于对照药剂;田间防治小麦纹枯病等4种病害效果达85%以上;对非靶标生物安全,且不易产生抗药性。仿生合成的银泰原药对大白鼠毒性试验,经口、经皮 LD50 均为4640mg/kg,20%银泰乳油对大白鼠毒性试验,经口LD50为3160mg/kg,经皮 LD50 为2150mg/kg;亚慢性经口毒性(90d)试验雌为19.1mg/kg,雄为18.3mg/kg;Ames、细胞微核和染色体畸变试验均为阴性结果。
Yintai (p-hydroxy butrophenone) is a kind of bionic fungicides synthesized by simulating the lead compound of ginkgol isolated from the exosperm of ginkgo fruit. 8.3-time diluted solution of alcohol crude extract from the ginkgo fruit showed 100% inhibtion on the pathogen of apple canker (Valsa mali), and 50% inhibition for the 25-time solution. Both 200-time and400time solutions of ginkgol, extracted from external seed coat of ginkgo, had 100% inhibition on pathogen of apple canker(Valsa mali). EC50 of 20% Yintai ME against4kinds of pathogens, including apple canker, tomato gray mold, and so on, ranges from 17.26 mg/L to 48.43 mg/L, better than the contrast chemicals respectively. Field control effects on4kinds of diseases, e.g. , Rhizoctonia cerealis, are higher than 85%, with safety to non-target organisms, and no symptom of pesticide resistance. Both LD50of acute oral toxicity and LD50 of acute dermal toxicity to mouse are 4640 mg/kg by Yintai technical material, and 3160 mg/kg and 2150 mg/kg by 20% Yintai EC coorespondingly. Trials of subchronic toxicity (90days) revealed that oral toxicity was 19.1 mg/kg for female, and 18.3 mg/kg for male, with negative results on Ames test, micro-nucleus test, and chromosome-type aberration test.
Ginkgo biloba L. / ginkgol / bionic synthesis / Yintai / control effect
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