文章以探索痰湿质的分子机制为目的，在临床流行病学调查的基础上，分别选择6例典型痰湿质和6例典型平和质受试对象，采用 Affymetrix GeneChip Mapping 500K Array检测技术检测基因组DNA，结合前期基因表达谱芯片分析痰湿质的差异表达基因结果，筛选痰湿质相关基因及单核苷酸多态性位点。试对痰湿质与平和质组间表达有显著差异的442个基因进行分析，与平和质比较，初步筛选出痰湿质 5个相关基因共 6 个 SNP 位点。同时进一步对相关基因功能分析显示，痰湿体质相关基因主要基因功能为酶活性、固醇运载体 活性等功能，参与糖异生途径、脂肪酸生物合成途径、胆固醇代谢过程、脂肪酸氧化作用、棕色脂肪细胞分化、 细胞葡萄糖调节平衡作用、体温调节作用等生物学过程，痰湿质者在分子水平上具有代谢紊乱的总体特征， 对其分子生物学特征进行了初步探索。

To investigate the molecular mechanism for phlegm-dampness constitution,examining the genome DNA of peripheral blood cells of six phlegm-dampness constitution and six normal constitution by using Affymetrix GeneChip Mapping 500K Array.We had identified 442 genes with significant differences between the phlegm-dampness constitution and the normal constitution by using Affymetrix Gene Chip Human Genome U133 plus-2, base on research results of prophase, sieve the related gene and characteristics of single nucleotide polymorphisms( SNP) of phlegm-dampnessconstitution.5 related genes and 6 SNPs with significant differences were identified between the phlegm-dampness constitution and the normal constitution. Further biologianalysis on the genes identified between two constitution groups demonstrate that they are involved in enzyme activity,sterol transporter activity,participate in the biology process of lipid metabolism, cholesterol metabolic process,brown fat cell differentiation, gluconeogenesis and thermoregulation.These results indicate that the Molecular characteristic of phlegm-dampness constitution is related to metabolism disorder.