目的：分析连云港市病残儿童资料，通过孕前优生健康检查干预其近五年病残儿父母再生育，预防病残儿的发生风险。方法：对连云港市2008―2012年经过医学鉴定的病残儿的资料进行分析，比较其五年间数量、地区、性别分布、疾病顺位变化等，发放调查问卷了解其在生育病残儿之前的基本情况；再次怀孕后有无优生指导、超生排畸、唐筛、妊娠结局、分娩方式等调查，分析干预效果。结果：近五年通过医学鉴定符合病残儿童标准的1 046例五年间无明显变化；城区较农村多；男性较女性多；疾病顺位排序先天性心脏病位于第一位。通过干预，收回问卷中先天性心脏病父母再生育72例均为正常儿，其次脑瘫患儿父母再生育35例均为正常儿。结论：病残儿鉴定父母通过孕前优生健康检查，完成整个孕前保健、风险评估到个性化咨询指导一系列干预后再生育均为正常儿，干预效果明显，减少了不良妊娠结局的发生，对预防和降低再次生育病残儿的发生非常重要。

Objective：To analyze data of disabled children of Lianyungang City，to intervene disabled children parents checked in pregnancy healthy birth in nearly five years，and prevent the incidence of sick and disabled children. Methods：The condition of the change in the numbers，regional distribution，sex distribution，and classification of diseases were compared by the data of disabled children after medical identification of Lianyungang City in 2008―2012. Previous basic situation of procreation disabled children was understood by questionnaires issued in disabled children family，intervention effect was analyzed in eugenic guide of the hospital，malformations checking of color doppler imaging ，Tang screening，pregnancy outcome and delivery way. Result：There has no obvious change of 1 046 cases of disabled children according with the standard of the medical identification in nearly five years，the town was more than the countryside，the boys was more than the girls，congenital heart disease ranged the first site in the disease sequence. According to intervention，72 reproduction parents questionnaire of congenital heart disease was normal and 35 reproduction parents of cerebral palsy ranging the second in the disease sequence was also normal .Conclusion：It is obvious that disabled childish parents according to progestational health check perform a series of intervention in preconception care from health education and risk assessment to personal consultant and give birth to all normal children，it cut down the happening of ill-natured pregnancy outcome and disabled childish birth.