The 17th CPC National Congress stressed that great efforts should be made to promote the integration of informatization and industrialization. The report of the 18th CPC National Congress supposed that efforts should be made to promote ‘the integration of information technology (IT) application and industrialization’ during its elaboration of the harmonious development of the harmonized development of industrialization, IT application, urbanization and agricultural modernization. Recently, the State Council has released “Made in China 2025” which puts forward in building an internationally competitive manufacturing industry. This paper analyzes the supporting role of the information service industry at all links of the value chain of the manufacturing industry from the perspective of integration of informatization and industrialization, and with the goal of development of first-class manufacturing industry in the world. It points that the weakness of information infrastructure and the lack of innovation awareness are the problems and challenges in the integration process through case studies and company surveys. Based on the results, it also gives the suggestion to develop manufacture-oriented information service industry.