The people-to-people and cultural exchanges in the engineering technology field refer to the exchanges of different scientific and technological knowledge and values formed during transformation or creation of things. Its purpose is to reduce or eliminate the estrangement in engineering ideas among different countries, so as to enhance people-to-people bond and ensure the smooth implementation of engineering projects. This paper first introduces the connotation of people-to-people and cultural exchanges in the engineering technology field and the significance of enterprises participation, then studies the status quo of participation of key enterprises along the Belt and Road, analyzes the problems existing in enterprises participation, and further proposes preliminary suggestions on how to deepen the participation of Chinese enterprises in the exchanges.