The paper elaborates the important practical and strategic significances of the globalization of China’s high-speed railway on China’s diplomacy, security, politics, economy and culture; and the three key strategic points must be emphasized. Furthermore , the paper analyzes the strategic opportunities and threatens facing to the globalization of China’s high-speed railway. Based on this, the paper put forwards to five strategic principles, including the layout importance, the timing urgency, the path feasibility, the regional difficulty and the railway interconnection. Furthermore, this paper makes following suggestions for the globalization strategy of China’s high-speed railway: integrating strategy implementations, rallying industry forces, constructing the training systems, building national research centers and innovating investment and financing.