Vaccination plays an important role in large-scale and intensive commercial marine fish farming. Vaccines can have significant positive impact on the reduced usage of antibiotics and have been a key reason for the successes of the healthy and sustainable development in marine fish aquaculture industries of developed countries and regions in the world. China, the world's largest fish producer, has been in the time of industrial transformation and upgrading on marine fish farming, however the increasing serious problems of fish diseases and food safety have been becoming one of the executing barriers for the greater progress in marine fish farming. With continuous technical breakthroughs in research and commercial development of marine fish vaccines funded by National industry system of flounder fishes, vaccination will be the core strategy of disease control and prevention in China's marine fish aquaculture.