This paper numerically simulates the stress development and generates a three-dimensional model of the medium-deep hole blasting in infinite rock mass for continuous charge and divided charge in blasting by using the large-scale nonlinear dynamic analysis software LSDYNA and the elastic- plastic model *MAT_PLASTIC_KINEMATIC and JwL. The difference of the decreasing rate in Von Mises effective stress of blasting，element effective stress peak in free face，the bore wall stress and acceleration are investigated. It is shown that divided charge could greatly improve the blasting effect by engineering blasting practice.