Urban underground space is important and necessary part for urban comprehensive anti-disaster. Along with the acceleration of urbanization and underground space use, urban comprehensive anti-disaster is facing challenges. International scholars have paid more attention to urban comprehensive anti-disaster with using the anti-disaster features of underground space. Analyzing typical engineering examples and research development of the role of underground space in urban comprehensive anti-disaster, some suggestions with regard to using underground space for urban comprehensive anti-disaster in our country are put forward, which is also reference for underground space using in our country.