Seismic exploration method, a kind of the geophysical exploration methods, has a wide range of application, which is not only good at oil and gas resources exploration areas, but also other mineral deposits. This paper mainly expounds the technical ideas in oil and gas exploration, combined with rich potassium brine of the seismic response characteristics, determine the formation of deep rich potassium brine of seismic data interpretation method and application effect. The author summarizes the seismic exploration technology and process which is used to explain the looking for brine mineral resources. The practical application in a rich brine potassium of the eastern Sichuan Basin shows that the seismic prospecting method can better delineation of potassium rich brine reservoir, and then put forward exploration prospect area.