Based on Edong Bridge, which is the second longest hybrid girder cable-stayed bridge with 926 m long main span,the influencing factors and crucial techniques of the main span closure method for long span hybrid girder cable-stayed bridge are studied. After theoretical analysis, numerical evaluation and practical test, the loading assistant closure method is employed in Edong Bridge. The loading assistant closure method, with better thermal adaptability and less influence on bridge line and the forced status,can meet the requirements of the unstressed state control method. Based on the mentioned advantages,the loading assistant closure method is applicable to long span hybrid girder cable-stayed bridges. The conclusion can provide reference for the further design of the similar bridges.