As an inevitable product of the sustainable development of national social-economy, high-speed rail and its stations will undoubtedly facilitate the forming and development of regional economy integration process as well as metropolis, thus stimulating and supporting the socio-economic development. High-speed rail has ushered in a new era of great opportunities since the Sixteenth National Congress with 139 new stations for high-speed rail completed by March 2011, like Beijing South Station, Wuhan Station, Guangzhou South Station, Shanghai Hongqiao Station and etc. The paper analyzes the interaction between high-speed rail station and social-economy and proposes the project and project portfolio dynamic interactive model and management theory taking social-economic development evolving regularities as its guiding strategy, offering theoretical basis for formulating the strategic goal system of high-speed rail station projects as well as program and single project management.