According to the feature of sandstone weathered and absorbed water heavily, the authors analyzed the physical and mechanical properties and chemical composition of the sandstone experimentally, then studied influence of blasting disturbance, water content, sample bedding on stress-strain strength characteristics through uniaxial and triaxial compression tests, and found that the sandstone would become weak in the strength when it absorbed water, and its cohesion decreased and showed significant anisotropy while friction angle was not changed. After the sandstone underwent blasting, its uniaxial compressive resistance and elastic modulus decreased, and Poisson ratio increased. As the sandstone has obvious bedding properties, the strengths of sample obtained from two different loading irections are different obviously. Based on the stress-strain curves from the triaxial tests, the authors found the stress-strain curves could be described well by the modified Duncan-Zhang model.