A mathematical model was developed for predicting smoke filling combined with sprinkler cooling and natural smoke exhaust. Experiments were carried out to validate the model, with experimental results, smoke filling characteristics are obtained. Results showed that smoke filling velocity combined with sprinkler cooling and natural smoke exhaust has a very small difference; the final height of smoke reduces with sprinkler cooling; for the range of pressure studied in the present investigation, we found only a small effect of pressure on the final height of smoke.